Marcos Alonso (£6.5m) has returned to the Chelsea starting XI ahead of the Gameweek 25 meeting with Huddersfield Town at Stamford Bridge.
Antonio Rüdiger (£6.0m) drops to the bench to allow Andreas Christensen (£5.0m) his first start since Gameweek 15.
Gonzalo Higuain (£9.5m) leads the line once again, flanked by Eden Hazard (£10.9m) and Willian (£7.2m).
Those interested in the Double Gameweek players on offer at Everton will be pleased to know that Gylfi Sigurdsson (£7.4m) and Richarlison (£6.8m) both start in their favoured positions of central and left attacking midfield respectively.
Vicente Guaita (£4.2m) is back in goal again for Crystal Palace after missing out on Gameweek 23 and returning in Gameweek 24.
Christian Benteke (£6.3m) is the chosen replacement for the suspended Wilfried Zaha (£6.7m), with new signing Michy Batshuayi (£6.5m) named among the substitutes.
Chris Hughton looks to have gone with 4-3-3 for Brighton once again, with Jurgen Locadia (£5.3m) and Solly March (£5.0m) flanking Glenn Murray (£6.3m).
Daryl Janmaat (£4.9m) gets a second consecutive start at right-back for Watford, while Ken Sema (£4.6m) features from the beginning for the first time since Gameweek 23.
As expected, Gerard Deulofeu (£5.5m) and Troy Deeney (£6.0m) are the strike pairing for the Hornets.
Johann Berg Gudmundsson (£5.5m) is on the bench for Burnley as Dwight McNeil (£4.4m) makes a sixth consecutive start on the Clarets’ left wing.
That means a first Premier League start for Callum Slattery (£4.5m) alongside Oriol Romeu (£4.3m) in central midfield.
Brighton XI: Ryan; Bong, Dunk, Duffy, Montoya; Groß, Stephens, Pröpper; Locadia, Murray, March.
Watford XI: Foster, Janmaat, Cathcart, Mariappa, Holebas, Hughes, Cleverley, Capoue, Sema, Deeney, Deulofeu.
Burnley XI: Heaton; Taylor, Mee, Tarkowski, Bardsley; McNeil, Westwood, Cork, Hendrick; Wood, Barnes.
Southampton XI: McCarthy; Bednarek, Stephens, Vestergaard; Ward-Prowse, Slattery, Romeu, Targett; Armstrong; Redmond, Ings.
Chelsea XI: Kepa; Alonso, D Luiz, Christensen, Azpilicueta; Barkley, Jorginho, Kanté; Hazard, Higuain, Willian.
Huddersfield XI: Lössl; Löwe, Schindler, Kongolo, Smith; Bacuna, Billing, Mooy; Mbenza, Kachunga, Diakhaby.
Crystal Palace XI: Guaita; Wan-Bissaka, Tomkins, Sakho, van Aanholt; Townsend, McArthur, Milivojevic, Schlupp; Ayew, Benteke.
Fulham XI: Rico; Odoi, Le Marchand, Ream; Christie, Chambers, Seri, Bryan; Cairney, Mitrovic, Babel.
Everton XI: Pickford; Coleman, Zouma, Keane, Baines; Davies, André Gomes; Walcott, Sigurdsson, Richarlison; Tosun.
Wolves XI: Rui Patrício; Bennett, Coady, Boly; Doherty, Dendoncker, Rúben Neves, João Moutinho, Jonny; Jiménez, Jota.