Three £4.0m defenders have earned Gameweek 1 starts, two of them coming in the same match.
As predicted from our research of pre-season, John Lundstram (£4.0m) is deployed in the central midfield trio of Sheffield United, while Diego Rico (£4.0m) starts at left wing-back for Bournemouth.
The match at the Vitality Stadium also includes a Premier League debut for Cherries goalkeeper Aaron Ramsdale (£4.5m) who appears to have won the hotly contested race to start between the sticks.
Fantasy managers backing Ryan Fraser (£7.5m), Callum Wilson (£8.0m) and Josh King (£6.5m) will be happy to see them on the team sheet.
Callum Robinson (£5.5m) starts up front for Sheffield United alongside David McGoldrick (£5.5m).
Meanwhile, Martin Kelly (£4.0m) features at centre-back alongside Scott Dann (£4.5m) for Crystal Palace.
The Eagles are still without Wilfried Zaha (£7.0m), who sitds on the bench. Christian Benteke (£6.0m) and Jordan Ayew (£5.0m) lead the attack.
There are few surprises for visitors Everton as Seamus Coleman (£5.5m) holds onto his right-back berth for now and Dominic Calvert-Lewin (£6.0m) starts up front with Moise Kean (£7.0m) on the bench,.
Those unfamiliar with Graham Potter’s version of Pep Roulette were given a harsh introduction to it on Saturday afternoon.
After naming an unchanged 3-4-3 line-up for the last two pre-season friendlies, which included starts for Leandro Trossard (£6.0m) in the front trio, he has gone with 3-5-2 for the trip to Watford and benched the new Belgian signing.
Glenn Murray (£6.0m) and Jurgen Locadia (£5.5m) start in the front two while Pascal Groß (£6.5m) comes into central midfield alongside Davy Pröpper (£5.0m) and Dale Stephens (£4.5m).
Dan Burn (£4.5m) joins Lewis Dunk (£4.5m) and Shane Duffy (£5.0m) in the three-man defence while Solly March (£5.0m) and Martin Montoya (£4.5m) are the wing-backs.
Hosts Watford have gone with a 4-4-2 formation but Gerard Deulofeu (£6.5m), reclassified as a forward for 2019/20, has been named on the left wing of midfield.
Troy Deeney (£6.5m) and Andre Gray (£6.0m) lead the Hornets’ line.
TEAMS IN FULL
Bournemouth XI: Ramsdale; Aké, S Cook, Mepham; Rico, Billing, Lerman, Smith; Fraser, Wilson, King.
Sheffield United XI: Henderson; O’Connell, Egan, Basham; Stevens, Fleck, Norwood, Lundstram, Baldock; Robinson, McGoldrick.
Burnley XI: Pope; Pieters, Mee, Tarkowski, Lowton; McNeil, Westwood, Cork, Gudmundsson; Wood, Barnes.
Southampton XI: Gunn; Bednarek, Stephens, Vestergaard; Valery, Ward-Prowse(C), Oriol Romeu, Bertrand; Adams, Redmond; Ings.
Crystal Palace XI: Guaita; van Aanholt, Dann, Kelly, Ward; Meyer, McArthur, Milivojevic, Townsend; Ayew, Benteke.
Everton XI: Pickford; Digne, Keane, Mina, Coleman; Schneiderlin, A Gomes; Bernard, Sigurdsson, Richarlison; Calvert-Lewin.
Watford XI: Foster; Kiko Femenía, Dawson, Cathcart, Holebas; Capoue, Doucouré; Hughes, Deulofeu; Deeney(C), Gray.
Brighton XI: Ryan; Duffy, Dunk(C), Burn; Montoya, Pröpper, Stephens, Groß, March; Locadia, Murray.