There are six Premier League matches taking place this evening, with all bar the Merseyside derby kicking off at 19:30 GMT.
Liverpool v Everton gets underway at 20:15 GMT, meanwhile.
Perhaps the headline team news comes from Stamford Bridge, where Chelsea take on Aston Villa.
Frank Lampard is able to call upon Tammy Abraham (£7.9m) as the England striker makes a swift return from the hip injury that forced his absence in Gameweek 14.
Mason Mount (£6.6m), Christian Pulisic (£7.5m) and the recalled Willian (£7.1m) make up the attacking trident behind Abraham but there is no place in the starting XI for Fikayo Tomori (£4.9m), who is replaced by Andreas Christensen (£4.9m).
Jorginho, Emerson (£5.5m), Olivier Giroud (£6.6m) and Pedro (£6.8m) also drop out of the team, as N’Golo Kante (£5.0m) and Cesar Azplicueta (£5.9m) return.
Dean Smith has made three changes, two of which are enforced.
Douglas Luiz (£4.5m), the suspended Frederic Guilbert (£4.4m) and the injured Anwar El Ghazi (£5.5m) make way, with Marvelous Nakamba (£4.4m), Ahmed El Mohamady (£4.2m) and Trezeguet (£5.2m) taking their places.
The swirling media reports that suggested that Anthony Martial (£7.7m) would miss out have proven to be accurate, with the Frenchman not in Manchester United’s squad.
Speaking to MUTV before the game, Ole Gunnar Solskjaer said:
Anthony got a slight injury on Sunday so he’ll be out for a little while.
Brandon Williams (£4.1m), Juan Mata (£6.2m) and Andreas Pereira (£5.0m) all drop to the bench, meanwhile, as Jesse Lingard (£6.3m), Ashley Young (£5.4m), Mason Greenwood (£4.3m) and Scott McTominay (£5.1m) come into Ole Gunnar Solskjaer’s starting XI.
Jose Mourinho is back at Old Trafford after a 12-month absence and has made two changes to his Spurs team, with Harry Winks (£5.3m) and Lucas Moura (£7.0m) replacing Tanguy Ndombele (£5.8m) and Eric Dier (£4.9m).
There were shocks at Anfield, too, with Jurgen Klopp making five changes: two of which see Mohamed Salah (£12.2m) and Roberto Firmino (£9.4m) drop to the bench.
Xherdan Shaqiri (£6.3m) and Divock Origi (£5.2m) come in, while Adrian (£4.2m) replaces the suspended Alisson (£6.0m).
Everton are unchanged.
Brendan Rodgers has made only one change to his Leicester City XI, with Christian Fuchs (£4.3m) replacing the absent Ben Chilwell (£5.9m).
Chilwell reportedly has a minor groin injury.
Hayden Mullins, in temporary charge of Watford, also makes a sole alteration, with Troy Deeney (£6.2m) in for the injured Jose Holebas (£4.7m).
That would seem to indicate a change of shape, with the 3-5-2 abandoned for a back four.
Continuing that trend, Nuno Espirito Santo has only made one tweak to his Wolves starting XI: Romain Saiss (£4.4m), who was banned for the 1-1 draw against Sheffield United, ousts Max Kilman (£4.0m) at centre-half.
West Ham’s only change sees Sebastien Haller (£7.1m) come in for Michail Antonio (£6.9m), who failed a late fitness test.
There is just one alteration at St. Mary’s, meanwhile: Norwich City are unchanged, while Shane Long (£4.6m) starts in Michael Obafemi‘s (£4.9m) stead for the hosts.
Chelsea XI: Kepa; Azpilicueta, Zouma, Christensen, James; Kante, Kovacic; Pulisic, Mount, Willian; Abraham.
Aston Villa XI: Heaton; Targett, Mings, Konsa, Elmohamady; Hourihane, Nakamba, McGinn; Grealish, Wesley, Trezeguet.
Leicester City XI: Schmeichel; Fuchs, Soyuncu, Evans, Ricardo; Ndidi; Barnes, Maddison, Tielemans, Perez; Vardy.
Watford XI: Foster; Masina, Mariappa, Cathcart, Femenia; Capoue, Doucoure; Hughes, Deulofeu, Sarr; Deeney.
Liverpool XI: Adrian; Alexander-Arnold, Lovren, Van Dijk, Robertson; Wijnaldum, Milner, Lallana; Shaqiri, Mane, Origi.
Everton XI: Pickford; Digne, Keane, Mina, Holgate, Sidibe; Sigurdsson, Davies; Richarlison, Iwobi, Calvert-Lewin.
Manchester United XI: De Gea; Young, Maguire, Lindelof, Wan-Bissaka; Fred, McTominay; Rashford, Lingard, James; Greenwood.
Tottenham Hotspur XI: Gazzaniga; Vertonghen, Sanchez, Alderweireld, Aurier; Winks, Sissoko; Son, Dele Alli, Lucas Moura; Kane.
Southampton XI: McCarthy; Bertrand, Bednarek, Stephens, Cedric; Redmond, Ward-Prowse, Hojbjerg, Djenepo; Ings, Long.
Norwich XI: Krul; Byram, Zimmermann, Godfrey, Aarons; Trybull, Amadou; Hernandez, McClean, Cantwell; Pukki.
Wolves XI: Patricio; Saiss, Coady, Dendoncker; Jonny, Neves, Moutinho, Doherty; Jota, Jimenez, Traore.
West Ham XI: Martin; Cresswell, Balbuena, Ogbonna, Fredericks; Rice, Noble; F. Anderson; Fornals, Snodgrass; Haller.
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