The final two fixtures of a truncated Gameweek 28 kick off simultaneously at 14:00 GMT.
Everton play host to Manchester United at Goodison Park, while Tottenham Hotspur face Wolverhampton Wanderers in north London.
The stand-out storyline on Merseyside is Anthony Martial‘s (£8.0m) inclusion in the United starting XI, three days after he missed out on the Red Devils’ Europa League win over Bruges with a thigh problem.
Martial wasn’t spotted at the team hotel ahead of this fixture but, not for the first time, a no-show at the Lowry didn’t translate into an absence from the United side.
Bruno Fernandes (£8.3m), the most-bought Fantasy Premier League asset of Gameweek 28, also starts today.
Ole Gunnar Solskjaer has made only one alteration from last weekend’s win over Watford, with Scott McTominay (£4.9m) replacing the injured Daniel James (£5.8m).
Solskjaer said ahead of kick-off:
It was just a precaution on Thursday, [Martial] probably could have played. We didn’t take the risk though, knowing Odion was going to play well and there would be no problem.
[James] got a knock on Thursday but he’ll be fine for Thursday [against Derby in the FA Cup] or definitely next weekend so not too much to worry about.
Richarlison (£8.3m) and Dominic Calvert-Lewin (£6.3m) continue their partnership up top for the hosts but elsewhere, Carlo Ancelotti is proving increasingly difficult to second-guess.
The Italian has made five changes from the 3-2 defeat to Arsenal, with Theo Walcott (£6.2m) returning from injury and Andre Gomes (£5.2m) making his first start in over three months.
Seamus Coleman (£5.3m), Michael Keane (£5.2m) and Tom Davies (£5.3m) are also recalled, with Djibril Sidibe (£5.1m), Yerry Mina (£5.3m), Fabian Delph (£5.3m), Alex Iwobi (£5.6m) and the injured Morgan Schneiderlin (£4.4m) dropping out.
The big news from the Tottenham Hotspur Stadium is that Adama Traore (£5.9m) is recalled to the Wolves starting XI, with Nuno Espirito Santo changing back to a 3-4-3 for this encounter.
Leander Dendoncker (£4.4m) makes way, while Santo’s other alteration is enforced: Ruben Vinagre (£4.2m) in for Jonny (£5.4m) at wing-back.
Jose Mourinho has made four changes to his Spurs side for this afternoon’s clash.
Tanguy Ndombele (£5.8m), Toby Alderweireld (£5.3m) and Jan Vertonghen (£5.2m) are all benched, while Hugo Lloris (£5.3m) is missing from the squad altogether with a groin problem.
Paolo Gazzaniga (£4.2m) comes in for the hosts’ goalkeeper, with Eric Dier (£4.8m), Serge Aurier (£5.0m) and Dele Alli (£8.3m) also returning to the side.
Mourinho said ahead of kick-off:
Hugo Lloris doesn’t feel in a condition to play. He’s played a couple of matches with a little problem which he was able to hide, but this time it wasn’t possible.
It’s another opportunity for Paolo to play and another challenge for the team. [Lloris] is obviously a very experienced and quality keeper, but life is made of challenges and we know we will have to fight until the end of the season, and we play against a very difficult opponent, of course.
Everton XI: Pickford, Coleman, Keane, Holgate, Baines, Davies, Gomes, Walcott, Calvert-Lewin, Sigurdsson, Richarlison.
Man Utd XI: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, Matic, Fred, Fernandes, McTominay, Martial, Greenwood.
Wolves XI: Patricio, Boly, Coady, Saïss, Doherty, Neves, Moutinho, Vinagre, Traoré, Jiménez, Jota.
Spurs XI: Gazzaniga, Aurier, Sanchez, Tanganga, Davies, Dier, Winks, Lo Celso, Dele, Bergwijn, Lucas.
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