Pep Guardiola has dealt Fantasy Premier League arguably the harshest blow of the season so far with his Gameweek 21 team-sheet.
Raheem Sterling (£11.6m), Riyad Mahrez (£8.1m), Joao Cancelo (£6.0m) and John Stones (£5.2m) are all among the substitutes as Manchester City host Sheffield United on Saturday afternoon.
Ilkay Gündogan (£5.8m), Phil Foden (£6.3m) and Ruben Dias (£5.9m) hold onto their starting berths amid all the changes.
Gabriel Jesus (£9.1m) returns to Manchester City’s line-up for the first time since the first match of Gameweek 19 while Foden and Ferran Torres (£6.9m) staff the flanks either side of him.
Aymeric Laporte (£6.0m) comes in for Stones at centre-back with Oleksandr Zinchenko (£5.5m) and Kyle Walker (£6.1m) on the left and right-hand side of defence respectively.
Sheffield United, as ever, line-up in a 3-5-2 formation with John Fleck (£5.6m), John Lundstram (£4.9m) and Oliver Norwood (£4.5m) in midfield while Rhian Brewster (£4.5m) and Oliver Burke (£4.2m) are up-front.
Also of encouragement for the Blades is a return on the bench for Oli McBurnie (£5.6m).
Manchester City are not the only team to rotate this afternoon as Tyrick Mitchell (£3.9m) drops to the bench for Patrick van Aanholt (£5.4m) to come in.
Jordan Ayew (£5.6m) and Michy Batshuayi (£5.7m) are paired up-front for Crystal Palace with Wilfried Zaha (£7.2m) dropping back to replace Andros Townsend (£5.6m) on the flanks of midfield.
Ruben Neves (£5.2m) and Adama Traoré (£6.0m) are on the bench for Wolves with João Moutinho (£5.2m) and new signing Willian José (£7.0m) come into the side.
Max Kilman (£4.0m) earns another start in the back-three while Romain Saïss (£5.0m) is not in the matchday squad.
West Bromwich Albion are in 5-4-1 for the meeting with Fulham featuring Robert Snodgrass (£5.7m) and Matheus Pereira (£5.6m) staffing the left and right-hand side of midfield.
And Ivan Cavaleiro (£5.3m) is the fall-guy at Fulham, dropping to the bench so Aleksandar Mitrović (£5.5m) can lead their 3-4-2-1 formation.
Gameweek 21 Line-ups
Crystal Palace XI: Guaita; Van Aanholt, Dann, Kouyaté, Clyne; Zaha, McCarthy, Milivojevic, Eze; Ayew, Batshuayi.
Wolves XI: Patricio; Kilman, Coady, Boly; Semedo, Dendoncker, Moutinho, Hoever; Neto, Willian José, Podence.
Manchester City XI: Ederson; Zinchenko, Laporte, Dias, Walker; B Silva, Fernandinho, Gündogan; Torres, Jesus, Foden.
Sheffield United XI: Ramsdale; Ampadu, Egan, Basham; Bogle, Fleck, Norwood, Lundstram, Baldock; Burke, Brewster.
West Bromwich Albion XI: Johnstone; Gibbs, Bartley, O’Shea, Ajayi, Furlong; M Pereira, Gallagher, Livermore, Snodgrass; C Robinson.
Fulham XI: Areola; Adarabioyo, Andersen, Aina; A Robinson, Anguissa, Lemina, De Cordova-Reid; Lookman, Loftus-Cheek; Mitrović.