In the final match of Gameweek 6, Crystal Palace host Brighton and Hove Albion at Selhurst Park in the M23 derby.
Kick-off is at 20:00 BST.
Odsonne Edouard (£6.5m) makes his first start for Palace, having scored twice as a substitute against Tottenham Hotspur in Gameweek 4.
Luka Milivojevic (£5.4m) also features in the starting XI, with Cheikhou Kouyate (£4.5m) and Christian Benteke (£6.3m) dropping to the bench alongside Jeremy Schlupp (£5.4m), who has recovered from a thigh problem.
Eberechi Eze (£5.9m) and Nathan Ferguson (£4.5m) remain sidelined.
As for Brighton, a win at Selhurst Park tonight would see them go top of the Premier League.
Robert Sanchez (£4.6m) and Shane Duffy (£4.3m) – who are currently owned by 25.4% and 22.5% of FPL managers respectively – both start, but Yves Bissouma (£4.6m) misses out with a knee injury and is replaced by Pascal Gross (£6.0m).
Dan Burn (£4.4m) is also in for Solly March (£5.4m).
Tariq Lamptey (£4.4m) again makes the bench, with Graham Potter stating last week that they will carefully manage his return to fitness.
GAMEWEEK 6 LINE-UPS
Crystal Palace XI: Guaita, Ward, Andersen, Guehi, Mitchell, Milivojevic, McArthur, Gallagher, Ayew, Zaha, Edouard
Subs: Butland, Kouyate, Kelly, Clyne, Schlupp, Hughes, Olise, Mateta, Benteke
Brighton XI: Sanchez, Veltman, Dunk, Duffy, Burn, Cucurella, Gross, Lallana, Trossard, Maupay, Welbeck
Subs: Steele, Lamptey, Connolly, MacAllister, Moder, Alzate, March, Roberts, Richards