Gameweek 24 comes to a conclusion on Wednesday evening as four top-flight matches take place.
Bournemouth v Chelsea and Southampton v Crystal Palace get us underway at 19:45 GMT, with Liverpool v Leicester City and Tottenham Hotspur v Watford scheduled to kick off at 20:00 GMT.
Marcos Alonso is benched for the first time in the league this season as Emerson Palmieri – who impressed in the Carabao Cup semi-final, second leg against Spurs – is handed a start at left-back, while Gonzalo Higuaín makes his Premier League bow up front for the Blues.
Eden Hazard is thus deployed on the left flank for Maurizio Sarri’s side, with Pedro getting the nod on the other wing.
The Cherries are without Callum Wilson this evening, with Joshua King leading the line for Eddie Howe’s side.
Ryan Fraser starts as expected, while there are places on the bench for January signings Dominic Solanke and Chris Mepham.
Son Heung-min is back in Spurs’ starting XI and looks set to play just off Fernando Llorente as Mauricio Pochettino once again deploys a wing-back system.
Christian Eriksen is also primed for a more advanced role but Kieran Trippier only makes the bench.
Javi Gracia has made three changes to his side from Watford’s last league outing, with Daryl Janmaat, Craig Cathcart and Will Hughes drafted in.
Virgil van Dijk has recovered from illness to line up at centre-half, with one of Jordan Henderson or Georginio Wijnaldum potentially filling in at right-back after a cursory look at the teamsheet.
Xherdan Shaqiri joins Sadio Mane, Mohamed Salah and Roberto Firmino in the Liverpool attack.
Claude Puel has made three alterations to his Leicester City side following the 4-3 defeat to Wolves: Jonny Evans, James Maddison and Marc Albrighton being handed recalls.
The fit-again Vicente Guaita returns between the sticks for Crystal Palace, with Wayne Hennessey named among the substitutes.
The Eagles are otherwise unchanged from the team that lost 4-3 to Liverpool in Gameweek 23.
Ralph Hasenhuttl has named the same eleven players in his starting XI that lined up against Everton, meanwhile.
Bournemouth XI (4-2-3-1): Boruc, Clyne, S Cook, Ake, Smith, Surman, Gosling, Stanislas, Fraser, Brooks, King.
Chelsea XI (4-3-3): Arrizabalaga, Azpilicueta, Rudiger, Luiz, Emerson Palmieri, Kante, Jorginho, Kovacic, Pedro, Higuain, Hazard.
Southampton XI (3-5-2): McCarthy, Bednarek, Stephens, Vestergaard, Valery, Hojbjerg, Romeu, Ward-Prowse, Targett, Redmond, Ings.
Crystal Palace XI (4-3-3): Guaita, Wan-Bissaka, Tomkins, Sakho, van Aanholt, Kouyaté, Milivojević, McArthur, Townsend, Ayew, Zaha.
Liverpool XI (4-2-3-1): Alisson, Henderson, van Dijk, Matip, Robertson, Wijnaldum, Keita, Shaqiri, Salah, Mane, Firmino.
Leicester City XI (4-2-3-1): Schmeichel, Ricardo, Evans, Maguire, Chilwell, Mendy, Ndidi, Albrighton, Gray, Maddison, Vardy.
Tottenham Hotspur XI (3-4-2-1): Lloris, Sanchez, Alderweireld, Vertonghen, Aurier, Winks, Sissoko, Rose, Eriksen, Son, Llorente.
Watford XI (4-4-2): Foster, Janmaat, Mariappa, Cathcart, Holebas, Hughes, Capoue, Cleverley, Pereyra, Deulofeu, Deeney.
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