Double Gameweek 32 comes to a head on Wednesday evening with three Premier League matches that all kick off at 19:45 BST.
Crystal Palace
The headline team news at the Etihad sees Pep Guardiola make seven changes, with Raheem Sterling, Bernardo Silva and David Silva among the players to drop to the bench.
Kyle Walker and Ilkay Gündogan are also among the substitutes, while Nicolas Otamendi drops out of the match-day squad.
Guardiola had previously ruled Sergio Aguero out of tonight’s match, so it is no shock to see Gabriel Jesus leading the line for City.
Leroy Sane and Riyad Mahrez will flank the Brazilian, while there is a first Premier League start of the season for Phil Foden.
Fernandinho, John Stones and Danilo are also recalled.
Neil Warnock has made only one change, with Harry Arter being replaced in the starting XI by Joe Ralls.
Maurizio Sarri has matched Guardiola in making seven alterations.
Eden Hazard returns to the Chelsea starting XI following his benching at Cardiff on Sunday, while there is a full Premier League debut for Callum Hudson-Odoi.
Gonzalo Higuain makes way for Olivier Giroud, while Emerson Palmieri replaces the injured Marcos Alonso.
N’Golo Kante, Ruben Loftus-Cheek and Andreas Christensen are recalled as Willian, Pedro, Ross Barkley, Mateo Kovacic and Antonio Rudiger drop out.
Chris Hughton has made four changes, the most eye-catching of which sees the fit-again Florin Andone replace Glenn Murray up front.
Solly March, Bruno and Gaetan Bong all start at the expense of Anthony Knockaert, Martin Montoya and Bernardo.
Son Heung-min returns to the Spurs starting XI, replacing Lucas Moura in the Lilywhites’ attack.
Ben Davies is preferred to Davinson Sanchez in Mauricio Pochettino’s only other change.
Roy Hodgson has brought Cheikhou Kouyate, James McArthur and Martin Kelly into his starting XI and benched Scott Dann, Max Meyer and Andros Townsend.
That means Jeffrey Schlupp will move even further upfield on the left of a front three, with Wilfried Zaha switching to the right flank.
Chelsea XI: Arrizabalaga, Azpilicueta, Christensen, Luiz, Emerson, Kante, Jorginho, Loftus-Cheek, Hudson-Odoi, Giroud, Hazard.
Brighton and Hove Albion XI: Ryan, Bruno, Duffy, Dunk, Bong, Bissouma, Stephens, Propper, March, Andone, Jahanbakhsh.
Manchester City XI: Ederson, Zinchenko, Stones, Laporte, Danilo, Fernandinho, Foden, De Bruyne, Sane, Mahrez, Jesus.
Cardiff City XI: Etheridge, Peltier, Morrison, Manga, Bennett, Gunnarsson, Ralls, Camarasa, Murphy, Hoilett, Niasse.
Tottenham Hotspur XI: Lloris, Alderweireld, Vertonghen, Davies, Trippier, Sissoko, Eriksen, Rose, Alli, Son, Kane.
Crystal Palace XI: Guaita, Wan-Bissaka, Tomkins, Kelly, Van Aanholt, Kouyate, Milivojevic, McArthur, Zaha, Batshuayi, Schlupp.
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