The north London derby brings Gameweek 4 to a close, with kick-off at the Emirates at 16:30 BST.
Unai Emery has given most Arsenal fans what they want and has united Alexandre Lacazette (£9.4m), Pierre-Emerick Aubameyang (£11.0m) and new signing Nicolas Pepe (£9.4m) in a starting XI for the first time this season.
With those three players playing in the attacking trident of a 4-3-3, there is no place for Dani Ceballos (£5.7m) – who is on the bench along with Mesut Ozil (£7.3m) and Joe Willock (£5.0m).
Ceballos was the most-bought player from either north London club heading into Gameweek 4.
Lucas Torreira (£4.9m) is back in central midfield, while Sead Kolasinac (£5.4m) replaces the Real Sociedad-bound Nacho Monreal (£5.0m) at left-back.
Mauricio Pochettino makes two changes from the side that were beaten 1-0 at home to Newcastle a week ago.
Christian Eriksen (£8.8m) starts in place of Lucas Moura (£7.5m), while the injured Kyle Walker-Peters (£5.0m) is replaced by Jan Vertonghen (£5.3m).
Pochettino confirmed in his pre-match interview that he will start with a back four despite the inclusion of three centre-halves, so Davinson Sanchez (£5.5m) shifts across to cover at right-back.
Dele Alli (£8.4m) is a substitute.
This fixture featured six goals last season, with Arsenal running out 4-2 winners.
Aubameyang’s biggest FPL score of the season came in that match, with the Gabonese forward racking up 16 points.
Kane scored penalties against the Gunners home and away in 2018/19.
He and Aubameyang are the fourth and fifth-most popular captaincy options of this Gameweek, although the England striker was the most-sold FPL forward of this weekend.
Arsenal XI: Leno, Maitland-Niles, Sokratis, Luiz, Kolasinac, Xhaka, Torreira, Guendouzi, Pepe, Lacazette, Aubameyang.
Spurs XI: Lloris, Sanchez, Alderweireld, Vertonghen, Rose, Winks, Sissoko, Eriksen, Lamela, Son, Kane.
4 years, 7 months agoGot 2 FT with this lot - question is do I make 3 or 4 transfers for -4 or -8 or wildcard? Quite a bit of dross in there and quite keen on the City triple up with Aguero. Players in capitals definitely need replacing anyway.
Heaton, Pope
Van Dijk, LAPORTE, Digne, Lundstram, Rico
Salah, Sterling, De Bruyne? SIGGY, Dendoncker
JOTA, KING, Greenwood