The seventh match of a goal-filled Saturday takes place at the Etihad, as league leaders Manchester City face Watford.
Kick-off is at 17:30 GMT.
Raheem Sterling and Sergio Aguero are joined in a front three by Riyad Mahrez, who replaces the injured Kevin De Bruyne in the City starting XI.
Bernardo Silva drops back into central midfield to take the place of the sidelined Belgian.
Vincent Kompany deputises for the injured John Stones in defence, while Aymeric Laporte is fit enough for a place on the bench.
Leroy Sane is also among the substitutes.
Javi Gracia has rotated heavily for the trip to Manchester, making seven changes in all.
Kiko Femenia, Miguel Britos, Christian Kabasele, Adam Masina, Tom Cleverley, Isaac Success and Andre Gray all come into the side, as Adrian Mariappa, Craig Cathcart, Jose Holebas, Will Hughes, Roberto Pereyra, Troy Deeney and Gerard Deulofeu make way.
Ben Foster, Daryl Janmaat, Etienne Capoue and Abdoulaye Doucoure are the only Watford players to keep their places.
Pep Guardiola’s side won the reverse fixture 2-1 back in December, when Mahrez registered his highest FPL score of the season (13 points).
Aguero was transferred in by over 125,000 Fantasy managers ahead of this Gameweek, despite City being without a fixture in Gameweek 31.
The Argentinean striker is the second-most-popular captaincy pick of this weekend, having been handed the armband by over 1.45 million FPL bosses.
Manchester City XI (4-3-3): Ederson, Walker, Kompany, Otamendi, Zinchenko, Bernardo Silva, Gündogan, Silva, Mahrez, Agüero, Sterling.
Watford XI (4-4-2): Foster, Janmaat, Britos, Kabasele, Masina, Kiko Femenia, Cleverley, Capoue, Doucoure, Success, Gray.
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