Sergio Aguero (£12.0m) returns to the Manchester City starting line-up as Tottenham Hotspur come to the Etihad Stadium.
The Argentinian striker comes in for Gabriel Jesus (£9.5m), who drops to the bench.
Also coming out of the side is Riyad Mahrez (£8.5m), who has been replaced by the returning Bernardo Silva (£8.0m).
Pep Guardiola has opted not to rotate his full-backs though as both Oleksandr Zinchenko (£5.5m) and Kyle Walker (£6.0m) retain their starting berths.
However, John Stones (£5.5m) drops out of the side altogether with a rectus femoris strain, so Nicolas Otamendi (£5.4m) comes in at centre-back.
Opponents Spurs have made just one change from the team that beat Aston Villa and it’s hard to argue that it’s the right one.
Christian Eriksen (£9.0m) featured only as a substitute in Gameweek 1 and transformed Spurs’ fortunes when he came onto the pitch.
Therefore, Mauricio Pochettino has put him back into the starting line-up for Gameweek 2, Lucas Moura (£7.5m) the man to make way.
Man City XI: Ederson; Zinchenko, Laporte, Otamendi, Walker; De Bruyne, Gündogan, Rodrigo; Sterling, Aguero, B Silva.
Spurs XI: Lloris; Rose, D Sánchez, Alderweireld, Walker-Peters; Ndombele, Sissoko, Winks; Eriksen, Lamela; Kane.
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