Anthony Martial (£7.7m) is set for another outing as Manchester United’s centre-forward this afternoon, as he leads the line against Crystal Palace.
Ole Gunnar Solskjaer has deployed Marcus Rashford (£8.7m) on the left flank of attacking midfield once again, Jesse Lingard (£6.5m) and Daniel James (£6.0m) joining him in that area of the pitch.
The Manchester United manager has opted to leave his back-four and holding midfield pairing of Scott McTominay (£5.0m) and Paul Pogba (£8.6m) unchanged.
Opponents Crystal Palace continue to offer a starting £4.0m option in defence as Martin Kelly (£4.0m) retains his place in the side.
Surprisingly, he has started the Gameweek 3 encounter ahead of Scott Dann (£4.5m), who must make do with a place on the bench as Gary Cahill (£4.5m) comes in for his Palace debut.
Meanwhile, Wilfried Zaha (£6.9m) starts up-front alongside Jordan Ayew (£5.0m).
Fantasy managers were given another taste of ‘Graham Potter Roulette’ on Saturday afternoon as the Brighton manager made changes to his side once again.
He has stuck with the 3-4-3 formation but Glenn Murray (£5.9m) and Pascal Groß (£6.5m) have dropped to the bench, with Florin Andone (£5.0m) and Neal Maupay (£6.0m) coming in.
Potter has kept faith in his three centre-backs and four midfield players once again, suggesting that his rotation this season may focus on those he uses in the attacking front-three.
Keeping his place in the side after scoring on his debut is Leandro Trossard (£6.0m), stationed on the left for Brighton once more.
Opponents Southampton have gone with a front three of Nathan Redmond (£6.4m), Danny Ings (£6.0m) and Che Adams (£5.9m).
The interest in John Lundstram (£4.1m) is sure to continue as he starts again for Sheffield United.
The injured John Fleck (£5.0m) comes out of central midfield allowing Luke Freeman (£5.5m) to get his first start for the Blades.
Callum Robinson (£5.4m) recovers from the knock that forced him off against Crystal Palace to keep his place up-front alongside David McGoldrick (£5.5m).
Despite some poor performances so far this season, Ayoze Pérez (£6.4m) retains his starting berth for Leicester, deployed on the right flank of midfield.
Finally, Gerard Deulofeu (£6.4m) is deployed in midfield for Watford with Andre Gray (£5.9m) leading the line on his own in a 4-2-3-1 formation.
West Ham will be buoyed by the return of Felipe Anderson (£6.9m) and Sébastien Haller (£7.4m) to the starting line-up.
Line-ups in Full
Brighton XI: Ryan; Burn, Dunk, Duffy; March, D Stephens, Pröpper, Montoya; Trossard, Andone, Maupay.
Southampton XI: Gunn; Danso, Vestergaard, Bednarek, Valery; Ward-Prowse, Højbjerg, Romeu; Redmond, Ings; Adams.
Man United XI: De Gea; Shaw, Maguire, Lindelöf, Wan-Bissaka; McTominay, Pogba; Rashford, Lingard, D James; Martial
Crystal Palace XI: Guaita; van Aanholt, Cahill, Kelly, Ward; Schlupp, Kouyaté, Milivojevic, McArthur; Ayew, Zaha.
Sheffield United XI: D Henderson; O’Connell, Egan, Basham; Stevens, L Freeman, Norwood, Lundstram, Baldock; Robinson, McGoldrick.
Leicester City XI: Schmeichel; Fuchs, Söyüncü, Evans, R Pereira; Choudhury; Maddison, Praet, Tielemans, A Pérez; Vardy.
Watford XI: Foster; Holebas, Cathcart, Dawson, Femenia; Capoue, Doucouré; Deulofeu, Cleverley, Hughes; A Gray.
West Ham XI: Fabianski; Masuaku, Ogbonna, Diop, Fredericks; Noble, Rice; Anderson, Lanzini, Yarmolenko; Haller.