The final Premier League match of the day is the meeting between Liverpool and Manchester United at Anfield.
Jurgen Klopp’s side thrashed United 7-0 in the corresponding fixture last season and will return to the top of the table with a win today.
Pressure is building on Erik ten Hag, meanwhile.
The Red Devils crashed out of Europe on Tuesday and have just one win in their last four Premier League games.
Kick-off is at 4.30pm GMT.
Liverpool boss Klopp makes just one change from the side that beat Crystal Palace 2-1 in Gameweek 16, with Ibrahima Konate partnering Virgil van Dijk at the back.
The Frenchman comes in for Jarell Quansah, who drops to the bench.
Erik ten Hag makes four alterations from the 3-0 loss to Bournemouth.
Harry Maguire, Sergio Reguilon, Bruno Fernandes and Anthony Martial are replaced by Jonny Evans, Raphael Varane, Kobbie Mainoo and Rasmus Hojlund.
GAMEWEEK 17 LINE-UPS
Liverpool XI: Alisson, Alexander-Arnold, Konate, van Dijk, Tsimikas, Endo, Szoboszlai, Gravenberch, Salah, Diaz, Darwin
Subs: Adrian, Kelleher, Gomez, Jones, Gakpo, Elliott, McConnell, Quansah, Bradley
Manchester United XI: Onana, Dalot, Varane, Evans, Shaw, Amrabat, Mainoo, Antony, McTominay, Garnacho, Hojlund
Subs: Bayindir, Rashford, Reguilon, Pellistri, Wan-Bissaka, van de Beek, Gore, Hannibal, Kambwala
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