There was instant disappointment for owners of two Arsenal assets as team news for Sunday’s Gameweek 17 matches came out.
Alexandre Lacazette (£9.6m) is on the bench once again, with Pierre-Emerick Aubameyang (£11.5m) preferred as the lone striker for the Gunners.
Meanwhile, Sead Kolasinac (£5.1m) misses out on Arsenal’s trip to Southampton after picking up a thigh injury in training on Saturday.
He is replaced at left-back by the returning Nacho Monreal (£5.4m), making his first start since Gameweek 8. With Rob Holding (£4.4m) injured and Shkodran Mustafi (£5.4m) and Sokratis Papastathopoulous (£5.1m) suspended, Laurent Koscielny (£5.4m) and Stephan Lichtsteiner (£4.5m) line-up at centre-back.
Aaron Ramsey (£7.3m) and Mesut Özil (£8.1m) are named on the bench.
There is a third Premier League start for young Southampton defender Jan Valery (£4.0m) while Danny Ings (£5.4m) recovers from his recent hamstring injury to feature for the first time since Gameweek 12.
At Brighton, there is another game at false-nine for Eden Hazard (£10.9m) who leads the Chelsea line, flanked by Pedro (£6.3m) and Willian (£7.3m).
Alvaro Morata (£8.5m) was not considered fit enough for the bench, where Olivier Giroud (£7.7m) has been named.
Meanwhile, Mateo Kovacic (£5.8m) comes through his injury doubt to start the match in central midfield.
Glenn Murray (£6.6m) leads the Brighton line with Pascal Groß (£6.7m) operating as the number 10.
Brighton XI: Ryan; Bernardo, Dunk, Balogun, Montoya; March, Stephens, Pröpper, Knockaert; Groß; Murray.
Chelsea XI: Kepa; Alonso, Rudiger, Luiz, Azpilicueta; Kovacic, Jorginho, Kante; Pedro, Hazard, Willian.
Southampton XI: McCarthy; Targett, Yoshida, Bednarek, Vestergaard, Valery; Redmond, Romeu, Hojbjerg, Armstrong; Ings.
Arsenal XI: Leno; Monreal, Koscielny, Lichtsteiner, Bellerín; Xhaka, Guendouzi, Torreira; Mkhitaryan, Iwobi; Aubameyang.
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