Nuno Espirito Santo has already begun the rotation process ahead of Wolves’ FA Cup semi-final next weekend.
Raúl Jiménez (£6.8m) and Matt Doherty (£5.4m) were both named on the bench for the Double Gameweek 32 trip to Burnley.
Diogo Jota (£6.1m) keeps his place leading the Wolves line, while Joao Moutinho (£5.3m) starts in midfield.
Elsewhere, there was good news for those with Marcus Rashford (£7.6m) in their squads as he was confirmed as starting against Watford.
The England international has been deployed up front alongside Anthony Martial (£7.2m).
Romelu Lukaku (£10.8m) and Jesse Lingard (£6.7m) were named among the substitutes although there was no place in the match squad for Victor Lindelof (£5.1m) after his wife gave birth earlier this week.
It’s Phil Jones (£5.1m) who is paired with Chris Smalling (£5.6m) at centre-back for Manchester United.
Meanwhile, opponents Watford have rested some players but have made fewer changes to their attack than Wolves as they prepare for the FA Cup semi-finals.
Troy Deeney (£5.9m) and Gerard Deulofeu (£5.7m) start up front of the first-choice four-man midfield.
Intriguingly, it’s in
Daryl Janmaat (£4.9m), Christian Kabasele (£4.4m) and Adam Masina (£4.3m) keep their places in the side after starting against Manchester City in Gameweek 30.
There was good news for those invested in Crystal Palace assets as Vicente Guaita (£4.2m), Aaron Wan-Bissaka (£4.5m), Jeffrey Schlupp (£4.5m), Luka Milivojevic (£6.3m) and Wilfried Zaha (£6.9m) all start.
There was some rotation for Brighton ahead of their involvement in the FA Cup semi-finals as Martín Montoya (£4.3m) and Bernardo (£4.2m) come in at full-back.
Chris Hughton has gone for a front-three of Anthony Knockaert (£5.2m) and Alireza Jahanbakhsh (£6.7m) either side of Glenn Murray (£6.3m).
Burnley keep faith in their front two of Ashley Barnes (£5.7m) and Chris Wood (£6.2m) while Jeff Hendrick (£5.2m) reclaims his starting berth on the right flank from Johann Berg Gudmundsson (£5.5m), who drops to the bench.
Brighton XI: Ryan; Bernardo, Duffy, Dunk, Montoya; Bissouma, Stephens, Pröpper; Knockaert, Murray, Jahanbakhsh.
Southampton XI: Gunn; Bertrand, Yoshida, Bednarek, Valery; Højbjerg, Romeu; Armstrong, Ward-Prowse, Redmond; Ings.
Burnley XI: Heaton; Bardsley, Tarkowski, Mee, Taylor; Hendrick, Westwood, Cork, McNeil; Barnes, Wood.
Wolves XI: Rui Patrício; Saïss, Coady, Boly; Traoré, Dendoncker, Rúben Neves, João Moutinho, Jonny; Cavaleiro, Diogo Jota.
Crystal Palace XI: Guaita; Wan-Bissaka, Tomkins, Dann, van Aanholt; Meyer, Milivojevic, Schlupp; Townsend, Batshuayi, Zaha.
Huddersfield XI: Hamer; Smith, Schindler, Kongolo, Durm; Bacuna, Hogg, Mooy; Pritchard, Löwe; Grant.
Leicester XI: Schmeichel; Ricardo Pereira, Morgan, Evans, Chilwell; Tielemans, Ndidi, Maddison; Gray, Vardy, Barnes.
Bournemouth XI: Begovic; Clyne, Mepham, Aké, Daniels; Brooks, Gosling, Lerma, Fraser; King, Wilson.
Man United XI:
Watford XI: Foster; Janmaat, Kabasele, Britos, Masina; Doucouré, Capoue; Hughes, Pereyra; Deulofeu, Deeney.
