Nathan Redmond (ยฃ5.4m) has been handed another start in the central attacking midfield role in which he thrived in Double Gameweek 34.
Having played as a makeshift centre-forward for long spells this season, the former Norwich man was paired with Josh Sims (ยฃ4.4m) last time out and got a brace.
Ralph Hasenhรผttl has gone with the same system in attack, handing another start to striker Danny Ings (ยฃ5.4m) too.
However, there was disappointment for those Fantasy managers who had invested in Southampton defender Yan Valery (ยฃ4.1m) with this Double Gameweek in mind.
After coming off with cramp in Double Gameweek 34 and overcoming that this week, he ends up missing the game through illness.
Jannik Vestergaard (ยฃ4.6m) is also absent making for a back-three of Maya Yoshida (ยฃ4.1m), Jan Bednarek (ยฃ4.0m) and Jack Stephens (ยฃ4.2m).
In central midfield there are starts for budget midfielders Oriol Romeu (ยฃ4.2m) and Pierre-Emile Hรธjbjerg (ยฃ4.4m), who will be in a handful of Bench Boost squads.
Meanwhile, Newcastle’s relevance to the Fantasy Premier League scene continues to dwindle.
Salomรณn Rondรณn (ยฃ5.9m) remains the most popular Magpie in the game but his ownership has fallen again, now to just 6.5% overall.
Newcastle XI: Dubravka; Schar, Lascelles, Dummett; Manquillo, Ki, Hayden, Ritchie; Almiron, Perez; Rondon
Southampton XI: Gunn; Bednarek, Yoshida, Stephens; Ward-Prowse, Oriol Romeu, Hรธjbjerg, Bertrand; Sims, Redmond; Ings.
