The final match of Gameweek 36 sees Manchester United take on Chelsea at Old Trafford.
Kick-off is at 16:30 BST.
A win for Chelsea would take them four points clear of Arsenal in fifth place and all but eliminate Manchester United from the race for a Champions League qualification spot.
United would move level on points with the Blues with a win this afternoon, however.
Ole Gunnar Solskjaer has made five changes to his Manchester United side from the midweek derby defeat.
Eric Bailly makes his first Premier League start in almost three months in central defence, with Chris Smalling the man to make way.
Juan Mata and Romelu Lukaku rejoin the United attack, with Jesse Lingard dropping out.
Nemanja Matic and Ander Herrera return in central midfield, with Fred, Andreas Pereira and Scott McTominay making way.
Smalling, Fred and Lingard are not even among the substitutes.
Gonzalo Higuain leads the line for Chelsea and will be flanked by Willian and Eden Hazard in the Blues’ attack.
Marcos Alonso, Antonio Rudiger and N’Golo Kante have all recovered from injury to start.
Willian, Alonso, Rudiger and Mateo Kovacic are the four changes that Maurizio Sarri has made from the 2-2 draw with Burnley.
Ruben Loftus-Cheek, Andreas Christensen, Emerson and the injured
Callum Hudson-Odoi drop out.
Manchester United XI: De Gea, Young, Bailly, Lindelof, Shaw, Herrera, Pogba, Mata, Matic, Lukaku, Rashford.
Subs: Romero, Darmian, Rojo, McTominay, Pereira, Sanchez, Martial.
Chelsea XI: Kepa, Azpilicueta, Rudiger, Luiz, Alonso, Kante, Jorginho, Kovacic, Willian, Hazard, Higuain.
Subs: Caballero, Christensen, Zappacosta, Barkley, Loftus-Cheek, Pedro, Giroud.