Raheem Sterling (Β£11.5m), the in-form Phil Foden (Β£6.3m) and Riyad Mahrez (Β£8.1m) start in a front three for Manchester City in their first game without the injured Kevin De Bruyne (Β£11.9m).
Popular budget midfielder Ilkay Gundogan (Β£5.6m) is part of a midfield three, with Rodri (Β£5.4m) and Bernardo Silva (Β£7.4m).
John Stones (Β£5.1m) and Ruben Dias (Β£5.9m) hope to continue their impress partnership at centre-back, with Joao Cancelo (Β£5.8m) and Oleksandr Zinchenko (Β£5.5m) at full-back.
Ederson (Β£6.0m) continues in goal.
Callum Robinson (Β£5.4m) is back up front for Sam Allardyce’s West Brom side.
Big Sam will be hoping Matheus Pereira (Β£5.6m) can continue his good form, alongside Karlan Grant (Β£5.8m), Robert Snodgrass (Β£5.7m), Jake Livermore (Β£4.7m) and Romaine Sawyers (Β£4.8m) in midfield.
Semi Ajayi (Β£4.8m) lines-up at centre-back with Dara O’Shea (Β£4.3m), with Kieran Gibbs (Β£4.3m) at left-back and Darnell Furlong (Β£4.5m) at right-back. Sam Johnstone (Β£4.5m) is in goal.
In the absence of Pierre-Emerick Aubameyang Β£11.3m), Alexandre Lacazette (Β£8.3m) starts up-front for Arsenal.
Bukayo Saka (Β£5.3m), Emile Smith Rowe (Β£4.5m) and Nicolas Pepe (Β£7.6m) are supporting Lacazette.
Granit Xhaka (Β£5.2m) and summer signing Thomas Partey (Β£4.9m) start in centre midfield.
With Kieran Tierney (Β£5.4m) missing through injury, Cedric Soares (Β£4.6m) starts at left-back, opposite Hector Bellerin (Β£5.1m).
Rob Holding (Β£4.5m) and David Luiz (Β£5.4m) line-up at centre back, with Bernd Leno (Β£5.0m) in goal.
Danny Ings (Β£8.3m) and Che Adams (Β£6.0m) are the Saints’ chosen front two, with Theo Walcott (Β£5.8m) and Stuart Armstrong (Β£5.5m) out wide.
Set piece specialist James Ward-Prowse (Β£6.1m) is in central midfield with Ibrahima Diallo (Β£4.5m).
With both first choice full-backs missing, Yann Valery (4.7m) starts at right-back, with Jake Vokins (Β£3.9m) at left-back. Jan Bednarek (Β£4.9m) and Jake Stephens (Β£4.6m) continue at centre-back. Alex McCarthy (Β£4.7m) is in goal.
Man City XI: Ederson; Cancelo, Stones, Dias, Zinchenko; Gundogan, Rodri, Mahrez; Bernardo, Foden, Sterling
West Brom XI: Johnstone; Furlong, Ajayi, OβShea, Gibbs; Snodgrass, Sawyers, Livermore, Grant, Pereira; Robinson
Southampton XI: McCarthy; Valery, Stephens, Bednarek, Vokins; Diallo, Ward-Prowse, Armstrong, Walcott; Ings, Adams
Arsenal XI: Leno; Bellerin, David Luiz Holding, Cedric Soares; Xhaka, Partey; Saka, Smith Rowe, Pepe; Lacazette
