Alvaro Morata serves a one-match ban for Chelsea’s trip to Everton, while West Ham’s Manuel Lanzini, Burnley’s James Tarkowski, Brighton’s Shane Duffy and Crystal Palace’s Christian Benteke also sit on the sidelines through suspension.
Wilfried Bony is out for Swansea City’s home clash with Palace but Shkodran Mustafi could return for Arsenal’s showdown against Liverpool tonight.
Here’s our summary of the key team news so far, with a whole host of big-name press conferences still to come later today.
Olivier Giroud is expected to miss Arsenal’s home clash against Liverpool tonight due to a hamstring injury but Francis Coquelin could shake off a knock to be in contention. Shkodran Mustafi may be available to return at centre-half following a thigh problem, so Nacho Monreal could move out of the middle and replace Ainsley Maitland-Niles at left-back.
Liverpool manager Jurgen Klopp welcomes back Emre Can for the trip to the Emirates following the midfielder’s one-match ban. Joel Matip has returned to training but tonight’s match may come too soon for the centre-back. Sadio Mane is likely to come into contention for a recall but Daniel Sturridge (illness) is doubtful.
Everton boss Sam Allardyce could name an unchanged side for the home meeting with Chelsea, with Dominic Calvert-Lewin leading the line once again.
The Blues will be without the suspended Alvaro Morata for the trip to Goodison Park after he picked up his fifth yellow card of the season in the 2-1 Carabao Cup victory over Bournemouth. Pedro, Willian and Eden Hazard look set to start in attack in a 3-4-2-1 set-up.
Shane Duffy will sit out Brighton & Hove Albion’s home fixture against Watford due to suspension, so Uwe Hunemeier or Connor Goldson will deputise in central defence.
The Hornets are without the suspended Marvin Zeegelaar, Abdoulaye Doucoure and Troy Deeney but Tom Cleverley is available again after serving a one-match ban. Will Hughes will undergo a late fitness test having returned to training following a hamstring injury but Kiko Femenia remains sidelined.
David Silva missed Manchester City’s 4-1 win over Tottenham Hotspur due to personal reasons, with Pep Guardiola hopefully set to provide an update on the midfielder in his press conference later this afternoon. Ilkay Gundogan could retain his start if the Spaniard is still unavailable. Vincent Kompany (muscle problem) and Eliaquim Mangala (head injury) are doubts for the home encounter against Bournemouth. Sergio Aguero looks the favourite to start up front after Gabriel Jesus played all 120 minutes in Tuesday night’s EFL Cup tie against Leicester City.
Cherries boss Eddie Howe has a number of injury concerns ahead of the trip to the Etihad. Jermain Defoe is set to miss out, while Charlie Daniels, Harry Arter and Josh King are all doubtful.
Cedric Soares is expected to miss Southampton’s home clash against Huddersfield Town, while fellow full-back Ryan Bertrand is also a doubt. After only coming on as a substitute in the 1-0 defeat to Chelsea, Charlie Austin should be handed a recall against the Terriers.
Huddersfield head coach David Wagner will be without the suspended Jonathan Hogg for the trip to St Mary’s, while Elias Kachunga has been ruled out for eight to 12 weeks with a knee injury. Danny Williams and Tom Ince could be handed recalls, though Chris Lowe remains a concern with a foot injury.
Stoke City manager Mark Hughes revealed that Erik Pieters and Kurt Zouma are both very doubtful for the home fixture against West Bromwich Albion. Charlie Adam will be assessed after picking up a hip problem, while Jese Rodriguez will need time to build up his fitness following a recent leave of absence due to personal reasons.
Alan Pardew revealed Matt Phillips and Nacer Chadli are likely to be in the travelling party for the trip to the bet365 Stadium. Gareth Barry is expected to push for a recall after scoring as a substitute in the 2-1 defeat to Manchester United.
Wilfried Bony has been ruled out for seven to ten days with a hamstring injury, and will miss Swansea City’s home meeting with Crystal Palace. Caretaker manager Leon Britton should hand a recall to Tammy Abraham, but Ki Sung-yeung (calf) and Leroy Fer (back) are both doubtful.
The Eagles will be without the suspended Christian Benteke for the trip to south Wales, so Bakary Sako could start alongside Wilfried Zaha in attack. Luka Milivojevic is available again following his one-match ban and is set to replace James McArthur but Joel Ward and Timothy Fosu-Mensah remain out.
Manuel Lanzini misses West Ham United’s home fixture against Newcastle United – he will serve the second of a two-match ban dished out for successful deception of a match official. Mark Noble is a doubt due to a hamstring injury.
The Magpies will be without the banned Jonjo Shelvey but Matt Ritchie and Dwight Gayle should push for recalls at the London Stadium.
Burnley will be without the suspended James Tarkowski for their home match against Tottenham Hotspur after the defender was handed a three-match ban by the FA for violent conduct. Kevin Long should deputise in central defence, while Charlie Taylor will continue at left-back with Stephen Ward very unlikely to recover from a knee injury.
As for Spurs, they welcome back Davinson Sanchez for the trip to Turf Moor following the defender’s three-match suspension. His return could allow Mauricio Pochettino to move Eric Dier into central midfield or switch to a three-man central defence.
After being rested for the EFL Cup tie against Man City, Kasper Schmeichel, Danny Simpson, Wes Morgan and Wilfred Ndidi should all return for the home clash against Manchester United.
Antonio Valencia is an injury concern for Jose Mourinho’s side due to a hamstring injury. Matteo Darmian, Luke Shaw and Daley Blind provide options in the full-back positions, with Ashley Young able to shift across to right-back.
All this and more has now been updated in the Team News section ahead of tonight’s 6.45pm deadline. Keep an eye on our official Twitter account for breaking news – as the day unfolds, we will issue updates from Friday’s press conferences and refresh our Team News tab accordingly to keep you informed.
