Pierre-Emerick Aubameyang (£11.4m) and Alexandre Lacazette (£9.6m) were both named on the Arsenal team sheet for Gameweek 16.
Unai Emery had rested the Frenchman in both of the Gunners’ previous two Premier League matches but he is back in the line-up for the first time since Gameweek 12.
Arsenal look to be lining up with a back-three and wing-backs with Stephan Lichtsteiner (£4.5m) coming in for the injured Rob Holding (£4.4m).
Glenn Murray (£6.7m) has been left among the substitutes for the fourth time in Brighton’s last six away matches. In his place is Florin Andone (£5.0m) making his second start in three. Leon Balogun (£4.2m) replaces the suspended Shane Duffy (£4.7m) at centre-back.
Romelu Lukaku (£10.7m) returns to the Manchester United starting line-up while Anthony Martial (£7.5m) was not considerd fit enough to face Fulham, and neither was Eric Bailly (£5.0m).
As expected, Javier ‘Chicharito’ Hernandez (£6.3m) leads the West Ham line in the absence of Marko Arnautovic but Lucas Perez (£6.2m) also gets a start. It will be interesting to see if he operates out wide or as a second centre-forward.
Meanwhile, Crystal Palace named an unchanged side from the line-up that lost 3-1 at Brighton midweek.
Arsenal XI: Leno; Kolasinac, Sokratis, Mustafi, Lichtsteiner, Bellerin; Guendouzi, Torreira, Xhaka; Aubameyang, Lacazette
Huddersfield XI: Lössl; Zanka, Schindler, Kongolo; Smith, Mooy, Hogg, Williams, Löwe; Pritchard; Depoitre.
Burnley XI: Hart; Bardsley, Tarkowski, Mee, Taylor; Johann Gudmundsson, Cork, Westwood, Brady; Wood, Barnes.
Brighton XI: Ryan; Bruno, Balogun, Dunk, Bernardo; Knockaert, Pröpper, Bissouma, March; Groß; Andone.
Cardiff XI: Etheridge; Ecuele Manga, Morrison, Bamba, Bennett; Mendez-Laing, Gunnarsson, Arter, Murphy; Camarasa; Paterson.
Southampton XI: McCarthy; Valery, Bednarek, Vestergaard, Targett; Højbjerg, Oriol Romeu; Redmond, Lemina, Armstrong; Austin.
Man United XI: De Gea; Dalot, Jones, Smalling, Young; Matic, Herrera; Rashford, Mata, Lingard; Lukaku.
Fulham XI: Rico; Odoi, Ream, Mawson, Bryan; Seri, Zambo Anguissa; Schürrle, Cairney, Sessegnon; Mitrovic.
West Ham XI: Fabianski; Zabaleta, Balbuena, Diop, Masuaku; Noble, Rice; Snodgrass, Felipe Anderson; Chicharito, Pérez.
Crystal Palace XI: Hennessey; Wan-Bissaka, Tomkins, Sakho, van Aanholt; McArthur, Milivojevic, Kouyaté, Meyer; Townsend, Zaha.
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