Unai Emery has named a much-changed starting XI for the North London derby.
Pierre-Emerick Aubameyang (£10.9m) and Sead Kolasinac (£5.1m) have both been named on the bench, much to the frustration of their Fantasy owners.
However, those assets are not the only ones to miss out, with midfield men Mesut Özil (£7.9m) and Lucas Torreira (£4.8m) also among the substitutes.
Those who have held onto Son Heung-min (£8.9m) will be quite excited to see a back-four seemingly made up entirely of centre-backs.
With Kolasinac and Ainsley Maitland-Niles (£4.4m) on the bench, Nacho Monreal (£5.4m), Laurent Koscielny (£5.4m), Sokratis Papastathopoulos (£5.1m), and Shkodran Mustafi (£5.4m) are the starting options in defence.
Harry Kane (£12.4m) and Son are the front two for Spurs, who are playing a 3-5-2 formation with Toby Alderweireld (£6.0m), Jan Vertonghen (£5.9m) and Davinson Sánchez (£5.8m) flanked by Kieran Trippier (£6.2m) and Danny Rose (£5.8m).
Spurs XI: Lloris, Trippier, Alderweireld, Sanchez, Vertonghen, Rose, Wanyama, Sissoko, Eriksen, Son, Kane.
Arsenal XI: Leno, Mustafi, Sokratis, Koscielny, Monreal; Guendouzi, Xhaka, Ramsey; Iwobi, Lacazette, Mkhitaryan.
