Nuno Espirito Santo has already begun the rotation process ahead of Wolves’ FA Cup semi-final next weekend.
Raรบl Jimรฉnez (ยฃ6.8m) and Matt Doherty (ยฃ5.4m) were both named on the bench for the Double Gameweek 32 trip to Burnley.
Diogo Jota (ยฃ6.1m) keeps his place leading the Wolves line, while Joao Moutinho (ยฃ5.3m) starts in midfield.
Elsewhere, there was good news for those with Marcus Rashford (ยฃ7.6m) in their squads as he was confirmed as starting against Watford.
The England international has been deployed up front alongside Anthony Martial (ยฃ7.2m).
Romelu Lukaku (ยฃ10.8m) and Jesse Lingard (ยฃ6.7m) were named among the substitutes although there was no place in the match squad for Victor Lindelof (ยฃ5.1m) after his wife gave birth earlier this week.
It’s Phil Jones (ยฃ5.1m) who is paired with Chris Smalling (ยฃ5.6m) at centre-back for Manchester United.
Meanwhile, opponents Watford have rested some players but have made fewer changes to their attack than Wolves as they prepare for the FA Cup semi-finals.
Troy Deeney (ยฃ5.9m) and Gerard Deulofeu (ยฃ5.7m) start up front of the first-choice four-man midfield.
Intriguingly, it’s in
Daryl Janmaat (ยฃ4.9m), Christian Kabasele (ยฃ4.4m) and Adam Masina (ยฃ4.3m) keep their places in the side after starting against Manchester City in Gameweek 30.
There was good news for those invested in Crystal Palace assets as Vicente Guaita (ยฃ4.2m), Aaron Wan-Bissaka (ยฃ4.5m), Jeffrey Schlupp (ยฃ4.5m), Luka Milivojevic (ยฃ6.3m) and Wilfried Zaha (ยฃ6.9m) all start.
There was some rotation for Brighton ahead of their involvement in the FA Cup semi-finals as Martรญn Montoya (ยฃ4.3m) and Bernardo (ยฃ4.2m) come in at full-back.
Chris Hughton has gone for a front-three of Anthony Knockaert (ยฃ5.2m) and Alireza Jahanbakhsh (ยฃ6.7m) either side of Glenn Murray (ยฃ6.3m).
Burnley keep faith in their front two of Ashley Barnes (ยฃ5.7m) and Chris Wood (ยฃ6.2m) while Jeff Hendrick (ยฃ5.2m) reclaims his starting berth on the right flank from Johann Berg Gudmundsson (ยฃ5.5m), who drops to the bench.
Brighton XI: Ryan; Bernardo, Duffy, Dunk, Montoya; Bissouma, Stephens, Prรถpper; Knockaert, Murray, Jahanbakhsh.
Southampton XI: Gunn; Bertrand, Yoshida, Bednarek, Valery; Hรธjbjerg, Romeu; Armstrong, Ward-Prowse, Redmond; Ings.
Burnley XI: Heaton; Bardsley, Tarkowski, Mee, Taylor; Hendrick, Westwood, Cork, McNeil; Barnes, Wood.
Wolves XI: Rui Patrรญcio; Saรฏss, Coady, Boly; Traorรฉ, Dendoncker, Rรบben Neves, Joรฃo Moutinho, Jonny; Cavaleiro, Diogo Jota.
Crystal Palace XI: Guaita; Wan-Bissaka, Tomkins, Dann, van Aanholt; Meyer, Milivojevic, Schlupp; Townsend, Batshuayi, Zaha.
Huddersfield XI: Hamer; Smith, Schindler, Kongolo, Durm; Bacuna, Hogg, Mooy; Pritchard, Lรถwe; Grant.
Leicester XI: Schmeichel; Ricardo Pereira, Morgan, Evans, Chilwell; Tielemans, Ndidi, Maddison; Gray, Vardy, Barnes.
Bournemouth XI: Begovic; Clyne, Mepham, Akรฉ, Daniels; Brooks, Gosling, Lerma, Fraser; King, Wilson.
Man United XI:
Watford XI: Foster; Janmaat, Kabasele, Britos, Masina; Doucourรฉ, Capoue; Hughes, Pereyra; Deulofeu, Deeney.
