Son Heung-min (£8.7m) and Kieran Trippier (£6.0m) are among the benched players for Spurs in their Double Gameweek 34 fixture.
With already-relegated Huddersfield coming to north London, Mauricio Pochettino has taken this opportunity to start Fernando Llorente (£5.1m) and Kyle Walker-Peters (£4.2m) in their place.
Christian Eriksen (£9.3m) has held onto his place in the side and without Trippier should have a greater involvement in set pieces.
Also, with Son on the bench and Harry Kane (£12.6m) injured, it is possible the Danish international could be taking the penalties too.
Ben Davies (£5.6m) comes in for Danny Rose (£5.8m) at left-back, while Juan Foyth (£5.0m) starts alongside Jan Vertonghen (£5.9m) and Davinson Sánchez (£5.8m) so that Toby Alderweireld (£6.0m) can have a rest on the bench.
Huddersfield
Chris Löwe (£4.4m) and Jon Stankovic (£3.9m) are both playing out of position in midfield.
Spurs XI: Lloris, Walker-Peters, Sanchez, Vertonghen, Foyth, Davies, Sissoko, Eriksen, Moura, Wanyama, Llorente
Huddersfield XI: Hamer; Durm, Kongolo, Schindler, Hadergjonaj; Löwe, Stankovic, Hogg, Bacuna, Kachunga; Grant.
