The clash between the Premier League’s top two is the headline act from Wednesday’s four Premier League matches.
The action at the Etihad gets underway at 20:00 BST, with Chelsea v Brentford and West Ham United v Liverpool kicking off 15 minutes earlier.
Nottingham Forest v Brighton and Hove Albion is first up at 19:30 BST.
Compared to the Manchester City side that drew with Bayern Munich a week ago, there is only one change: Kyle Walker in for the injured Nathan Ake.
Arsenal’s only alteration sees Granit Xhaka return to fitness and oust Fabio Vieira.
In the West Ham v Liverpool game, there is just one alteration across the two teams.
The Hammers are unchanged from the 4-0 thumping of Bournemouth, while Jurgen Klopp brings in Joel Matip for the injured Ibrahima Konate.
At Stamford Bridge, Cesar Azpilicueta and Raheem Sterling are in for the sidelined Reece James and Kai Havertz.
Opponents Brentford meanwhile recall Yoane Wissa, Mathias ‘Zanka’ Jorgensen, Frank Onyeka and Mads Roerslev, as Bryan Mbeumo, Kevin Schade and Aaron Hickey drop to the bench. Christian Norgaard is injured.
The big news from the City Ground is that Jason Steele gets the nod between the posts for visitors Brighton, with Robert Sanchez only a substitute.
Steele for Sanchez is one of three changes Roberto De Zerbi has made from the FA Cup semi-final on Sunday, with Levi Colwill and Facundo Buonanotte also coming in for Adam Webster and Danny Welbeck.
Brennan Johnson and Serge Aurier replace Scott McKenna and Remo Freuler in Steve Cooper’s couple of tweaks.
Aurier and substitute Cheikhou Kouyate were, naturally, described as “not quite ready yet” in their manager’s pre-match presser on Monday.
GAMEWEEK 33 LINE-UPS
Nottingham Forest XI: Navas, Aurier, Felipe, Niakhate, N Williams, Mangala, Danilo, Lodi, Gibbs-White, Johnson, Awoniyi.
Subs: Hennessey, Worrall, Lingard, Toffolo, Surridge, Kouyate, Freuler, Dennis, Ayew.
Brighton and Hove Albion XI: Steele, Gross, Dunk, Colwill, Estupinan, Caicedo, Mac Allister, March, Buonanotte, Mitoma, Enciso.
Subs: Sanchez, Webster, Welbeck, Undav, Ayari, Gilmour, Van Hecke, Veltman, Offiah.
Chelsea XI: Arrizabalaga, W Fofana, Thiago Silva, Chalobah, Azpilicueta, Fernandez, Kovacic, Chilwell, Kante, Gallagher, Sterling.
Subs: Badiashile, Aubameyang, Pulisic, Joao Felix, Loftus-Cheek, Mudryk, Mendy, Ziyech, Madueke.
Brentford XI: Raya, Roerslev, Jorgensen, Pinnock, Mee, Henry, Jensen, Onyeka, Janelt, Toney, Wissa.
Subs: Hickey, Schade, Dasilva, Ghoddos, Mbeumo, Damsgaard, Baptiste, Stevens, Cox.
West Ham United XI: Fabianski, Cresswell, Aguerd, Zouma, Coufal, Soucek, Rice, Benrahma, Paqueta, Bowen, Antonio.
Subs: Areola, Ogbonna, Kehrer, Emerson, Fornals, Lanzini, Downes, Cornet, Ings.
Liverpool XI: Alisson, Robertson, Van Dijk, Matip, Alexander-Arnold, Jones, Fabinho, Henderson, Jota, Gakpo, Salah.
Subs: Kelleher, Gomez, Tsimikas, Carvalho, Thiago, Milner, Elliott, Diaz, Nunez.
Manchester City XI: Ederson, Walker, Dias, Akanji, Stones, Rodri, Silva, De Bruyne, Gundogan, Grealish, Haaland.
Subs: Phillips, Laporte, Ortega, Alvarez, Gomez, Mahrez, Foden, Palmer, Lewis.
Arsenal XI: Ramsdale, White, Holding, Gabriel, Zinchenko, Odegaard, Partey, Xhaka, Saka, Jesus, Martinelli.
Subs: Tierney, Smith Rowe, Nketiah, Kiwior, Trossard, Jorginho, Vieira, Nelson, Turner.
