Four more Gameweek 22 matches take place on Sunday, with Ipswich Town v Manchester City following on from three 2pm GMT kick-offs.
Ange Postcoglou makes two changes from the team that lost to Arsenal on Wednesday, with Ben Davies and James Maddison starting over Yves Bissouma and Dominic Solanke, who miss out through injury.
Everton also make two alterations.
Jake O’Brien and Jesper Lindstrom are recalled by David Moyes, with Ashley Young and Jack Harrison dropping to the bench.
At Old Trafford, Ruben Amorim makes three changes to the side that beat Southampton on Thursday.
Out go Lisandro Martinez, Alajandro Garnacho and Rasmus Hojlund. Harry Maguire, Diogo Dalot and Joshua Zirkzee are their replacements.
Lewis Dunk comes in for Adam Webster at the back for Brighton and Hove Albion, while Yankuba Minteh and Danny Welbeck replace the injured Matt O’Riley and Simon Adingra further forward.
Finally, at Nottingham Forest, Nuno Espirito Santo makes just one alteration. Nicolas Dominguez comes into midfield with Ryan Yates dropping to the bench.
There are three changes made by Ivan Juric at the City Ground.
Lesley Ugochukwu, Kamaldeen Sulemana and the injured Tyler Dibling are replaced by Flynn Downes, Cameron Archer and Adam Armstrong.
LINE-UPS
Everton XI: Pickford, O’Brien, Tarkowski, Branthwaite, Mykolenko, Gueye, Mangala, Lindstrom, Doucoure, Ndiaye, Calvert-Lewin
Subs: Virginia, Begovic, Patterson, Keane, Harrison, Beto, Young, Armstrong, Sherif
Tottenham Hotspur XI: Kinsky, Porro, Dragusin, Davies, Spence, Gray, Bergvall, Sarr, Kulusevski, Maddison, Son
Subs: Austin, Regulion, Richarlison, Yang, Lankshear, Moore, Ajayi, Olusesi, Hardy
Manchester United: Onana, Yoro, de Ligt, Maguire, Mazraoui, Ugarte, Mainoo, Dalot, Amad, Fernandes, Zirkzee
Subs: Bayindir, Martinez, Malacia, Casemiro, Collyer, Eriksen, Antony, Garnacho, Hojlund
Brighton and Hove Albion XI: Verbruggen, Veltman, Dunk, van Hecke, Estupinan, Baleba, Ayari, Minteh, Joao Pedro, Mitoma, Welbeck
Subs: Steele, Lamptey, Webster, March, Enciso, Adingra, Rutter, Gomez, McConville
Nottingham Forest: Sels, Aina, Milenkovic, Murillo, Williams, Dominguez, Anderson, Elanga, Gibbs-White, Hudson-Odoi, Wood
Subs: Miguel, Morato, Awoniyi, Ward-Prowse, Moreno, Jota, Yates, Sosa, Boly
Southampton XI: Ramsdale, Sugawara, Bree, Bednarek, Harwood-Bellis, Walker-Peters, Downes, Fernandes, Aribo, Archer, Armstrong
Subs: McCarthy, Manning, Wood, Bella-Kotchap, Ugochukwu, Smallbone, Fraser, Onuachu, Kamaldeen
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