Six Premier League matches kick off at 15:00 BST today, with Manchester City v Brighton and Hove Albion among the games taking place this afternoon.
A number of key Fantasy Premier League assets have dropped to the bench, one of whom is Bernardo Silva: the Portugal international is replaced on the right flank by Riyad Mahrez for the second time this season.
Rodri ousts Ilkay Gundogan from central midfield in Pep Guardiola’s only other change.
Raheem Sterling, Sergio Aguero, Oleksandr Zinchenko and Kevin De Bruyne all start.
Graham Potter has had a bit of a reshuffle, with Solly March joining the front three and Bernardo coming in at left wing-back.
Adam Webster replaces Shane Duffy at centre-half, while there is another start for Leandro Trossard.
Fikayo Tomori makes his first start for Chelsea in place of Andreas Christensen, who drops to the bench.
That is Frank Lampard’s only change, with opposite number Chris Wilder also making only one alteration: Oli McBurnie in for David McGoldrick.
Ayoze Perez has paid the price for a sluggish start to the season as he drops to the bench for Leicester’s match with Bournemouth.
Ben Chilwell, Wilfred Ndidi, Harvey Barnes and Marc Albrighton are recalled as Christian Fuchs, Hamza Choudhury and Dennis Praet also make way.
Harry Wilson in for Charlie Daniels is Eddie Howe’s only change.
Javi Gracia has made three changes from the West Ham defeat and appears to be going with a wing-back system: Jose Holebas, the injured Etienne Capoue and Gerard Deulofeu make way, with Christian Kabasele, Daryl Janmaat and Roberto Pereyra taking their places.
Amid all the injury talk at Newcastle, there are only two changes: Christian Atsu and Jetro Willems in for the sidelined Allan Saint-Maximin and Matt Ritchie.
West Ham have named an unchanged side from their win against Watford, while Daniel Farke has made just one alteration from Gameweek 3: Christoph Zimmermann replacing the injured Grant Hanley at centre-back.
Dean Smith and Roy Hodgson have named unchanged teams from Gameweek 3 as Crystal Palace take on Aston Villa at Selhurst Park.
Chelsea XI: Kepa, Azpilicueta, Zouma, Tomori, Emerson, Jorginho, Kovacic, Pulisic, Barkley, Mount, Abraham.
Sheffield Utd XI: Henderson, Basham, Egan, O’Connell, Baldock, Freeman, Norwood, Lundstram, Stevens, McBurnie, Robinson.
Crystal Palace XI: Guaita, Ward, Kelly, Cahill, van Aanholt, Milivojevic, Kouyaté, McArthur, Schlupp, Zaha, Ayew.
Aston Villa XI: Heaton, Guilbert, Engels, Mings, Taylor, McGinn, Douglas Luiz, Grealish, Jota, Wesley, Trezeguet.
Leicester City XI: Schmeichel, Ricardo Pereira, Evans, Söyüncü, Chilwell, Ndidi, Albrighton, Tielemans, Maddison, Barnes, Vardy.
Bournemouth XI: Ramsdale, Mepham, Cook, Ake, Smith, H. Wilson, Billing, Lerma, Fraser, King, C. Wilson.
Manchester City XI: Ederson, Walker, Otamendi, Laporte, Zinchenko, Rodrigo, De Bruyne, D Silva, Sterling, Mahrez, Aguero.
Brighton XI: Ryan, Burn, Dunk, Webster, Montoya, Pröpper, Stephens, Bernardo, March, Maupay, Trossard.
Newcastle United XI: Dubravka, Schar, Lascelles, Dummett, Krafth, Hayden, Longstaff, Willems, Atsu, Joelinton, Almiron.
Watford XI: Foster, Dawson, Kabasele, Cathcart, Janmaat, Cleverley, Doucouré, Kiko Femenía, Hughes, Pereyra, Gray.
West Ham United XI: Fabianski, Fredericks, Diop, Ogbonna, Masuaku, Noble, Rice, Felipe Anderson, Yarmolenko, Lanzini, Haller.
Norwich City XI: Krul, Aarons, Zimmermann, Godfrey, Lewis, Leitner, Trybull, Cantwell, Stiepermann, Buendia, Pukki.
