There are six Premier League matches kicking off simultaneously this afternoon but there is only one place to begin with the team news.
Cristiano Ronaldo makes his first start for Manchester United since re-signing from Juventus last month and is one of two changes that Ole Gunnar Solskjaer has made to his starting XI from Gameweek 3.
Nemanja Matic also returns, with Fred dropping to the bench.
The Red Devils’ opponents, Newcastle United, make four changes to the side that drew 2-2 with Southampton last time out.
Callum Wilson is injured, with Joelinton replacing him up top.
Fabian Schar, Federico Fernandez and Jacob Murphy also make way, with Isaac Hayden, Ciaran Clark and Javier Manquillo recalled.
As for the ‘noisy neighbours’, Pep Guardiola has named an unchanged team for the third match in a row.
Brendan Rodgers makes three alterations from the Leicester side that begun the win at Norwich, with Ryan Bertrand and Jannik Vestergaard making their first Leicester starts. Timothy Castagne is also recalled.
Daniel Amartey, Ricardo Pereira and Luke Thomas drop out.
Ralph Hasenhuttl makes two tweaks to the Southampton team that salvaged a point at Newcastle, with Nathan Redmond and Romain Perraud brought in for the benched Che Adams and Kyle Walker-Peters.
West Ham boss David Moyes keeps faith with the same side for the fourth game in a row, with recent signings Kurt Zouma, Nikola Vlasic and Alex Kral all among the substitutes.
Watford make two changes from their 1-0 defeat by Spurs before the break. Both are at full-back, with Danny Rose and Jeremy Ngakia ousting Craig Cathcart and Adam Masina.
Wolves are unchanged again.
Mikel Arteta makes seven changes from the 5-0 defeat at Man City.
Kieran Tierney, Bukayo Saka, Martin Odegaard and Pierre-Emerick Aubameyang are the only four players to keep their places.
Aaron Ramsdale and Takehiro Tomiyasu make their debuts, while Emile Smith Rowe is only a substitute.
Daniel Farke makes four changes from his side’s last outing. Christos Tzolis, Lukas Rupp, Kieran Dowell and Andrew Omobamidele start, with Ben Gibson, Billy Gilmour, Milot Rashica and Todd Cantwell dropping to the bench.
Brentford make one change from the side that drew 1-1 at Aston Villa as Shandon Baptiste makes his first Premier League start, with Saman Ghoddos dropping to the bench.
Brighton hand a debut to Spain international defender Marc Cucurella, with Joel Veltman and Danny Welbeck also recalled.
GAMEWEEK 4 LINE-UPS
Arsenal XI: Ramsdale, Tierney, White, Gabriel, Saka, Odegaard, Aubameyang, Maitland-Niles, Tomiyasu, Pepe, Lokonga
Subs: Leno, Partey, Lacazette, Smith Rowe, Soares, Tavares, Chambers, Mari, Martinelli
Norwich XI: Krul, Aarons, Hanley, Rupp, Dowell, Tzolis, Lees-Melou, Williams, Pukki, Kenny McLean, Omobamidel
Subs: Gunn, Gibson, Gilmour, Cantwell, Kabak, Normann, Rashica, Sorensen, Idah
Brighton: Sanchez, Webster, Duffy, Dunk, Cucurella, Veltman, Lallana, Bissouma, Welbeck, Trossard, Maupay.
Subs: Steele, Scherpen, Roberts, March, Alzate, Richards, Locadia, Roberts, MacAllister.
Brentford: Raya, Pinnock, Jansson, Ajer, Henry, Janelt, Norgaard, Canos, Baptiste, Toney, Mbeumo.
Subs: Fernandez, Thompson, Ghoddos, Jensen, Onyeka, Zanka, Forss, Wissa, Roerslev.
Leicester XI: Schmeichel, Castagne, Soyuncu, Vestergaard, Bertrand, Albrighton, Ndidi, Tielemans, Barnes, Vardy, Maddison.
Subs: Ward, Amartey, Ricardo, Evans, Dewsbury-Hall, Soumaré, Daka, Lookman, Iheanacho.
Man City XI: Ederson, Walker, Dias, Laporte, Joao Cancelo, Bernardo Silva, Rodri, Gundogan, Gabriel Jesus, Torres, Grealish.
Subs: Carson, Stones, Ake, Sterling, Zinchenko, De Bruyne, Fernandinho, Mahrez, Foden
Man Utd XI: De Gea, Wan Bissaka, Varane, Maguire, Shaw, Pogba, Matic, Greenwood, Bruno Fernandes, Sancho, Ronaldo.
Subs: Heaton, Bailly, Dalot, Lindelof, Fred, Lingard, Mata, van de Beek, Martial
Newcastle XI: Woodman, Manquillo, Hayden, Lascelles, Clark, Ritchie, Willock, Longstaff, Almiron, Joelinton, Saint-Maximin.
Subs: Schar, Lewis, Hendrick, Krafth, Fernandez, Murphy, Darlow, Gayle, White.
Southampton XI: McCarthy, Livramento, Stephens, Salisu, Perraud, Elyounoussi, Ward-Prowse, Romeu, Djenepo, Redmond, Armstrong
Subs: Forster, Walker-Peters, Lyanco, Adams, Broja, Tella, Diallo, Bednarek, Valery
West Ham XI: Fabianski, Coufal, Dawson, Ogbonna, Cresswell, Soucek, Rice, Bowen, Fornals, Benrahma, Antonio
Subs: Areola, Zouma, Yarmolenko, Lanzini, Vlasic, Noble, Diop, Fredericks, Kral
Watford XI: Bachmann, Ngakia, Troost-Ekong, Sierralta, Rose, Etebo, Sarr, Sissoko, Kucka, Bonaventure, King.
Subs: Louza, Cleverley, Masina, Sema, Cathcart, Tufan, Kabasele, Hernandez, Elliot.
Wolves XI: Jose Sa, Kilman, Coady, Saiss, Nelson Semedo, Neves, Joao Moutinho, Marcal, Trincao, Jimenez, Traore.
Subs: Hoever, Ait Nouri, Daniel Podence, Mosquera, Boly, Silva, Ruddy, Hwang, Dendoncker.
