Bryan Mbeumo makes a first return to Brentford since his move from west London to Manchester United over the summer.
Kick-off in the Gameweek 6 curtain-raiser at the Gtech Community Stadium is at 12.30pm BST.
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TEAM NEWS
Mbeumo is joined in the visitors’ starting XI by Matheus Cunha, who made his return from a hamstring injury as a substitute last weekend.
That means that Rubem Amorim unites his big-money front three in a starting line-up for the first time, with Benjamin Sesko set to lead the line.
Cunha for the absent Amad Diallo, who has suffered a family bereavement, is one of three changes to United’s Gameweek 5 team.
Manuel Ugarte comes in for the suspended Casemiro in midfield, while the fit-again Diogo Dalot replaces the injured Noussair Mazrouai at wing-back.
Brentford boss Keith Andrews has made two alterations.
Aaron Hickey makes his first Premier League start in not far off two years, replacing Keane Lewis-Potter at left-back.
In an attacking move, Dango Ouattara comes in for Ethan Pinnock. That will see the Bees move to a 4-3-3, having used a 3-5-2 in recent weeks.
LINE-UPS
Brentford XI: Kelleher, Kayode, Collins, van den Berg, Hickey, Henderson, Damsgaard, Yarmolyuk, Schade, Ouattara, Thiago.
Subs: Valdimarsson, Henry, Pinnock, Ajer, Jensen, Onyeka, Milambo, Janelt, Lewis-Potter.
Manchester United XI: Bayindir, De Ligt, Maguire, Shaw, Dalot, Ugarte, Fernandes, Dorgu, Mbeumo, Cunha, Sesko.
Subs: Heaton, Lammens, Fredricson, Heaven, Leon, Yoro, Mainoo, Mount, Zirkzee.
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