In the final Premier League match of the day, there’s a small matter of a derby at the Etihad Stadium as Manchester City take on Manchester United.

Kick-off is at 16:30 GMT.

For the visitors, Ralf Rangnick will have to cope without Cristiano Ronaldo who has picked up a hip injury, along with Raphael Varane and Luke Shaw, both of whom have tested positive for Covid-19, plus Edinson Cavani.

That means Victor Lindelof and Harry Maguire feature at the heart of the defence, with Alex Telles operating at left-back.

Further forward, Scott McTominay comes in for Nemanja Matic, whilst Bruno Fernandes, Anthony Elanga and Jadon Sancho line-up in attack.

As for Man City, Pep Guardiola makes three changes to his starting XI, with Kyle Walker, Jack Grealish and Riyad Mahrez replacing Ruben Dias, Ilkay Gundogan and Raheem Sterling.

Dias, meanwhile, will be missing for at least four weeks after injuring his hamstring at Peterborough on Tuesday.

Nathan Ake and Cole Palmer are City’s only other absentees.

GAMEWEEK 28 LINE-UPS

Manchester City XI: Ederson, Walker, Stones, Laporte, Cancelo, Rodri, De Bruyne, Bernardo, Mahrez, Grealish, Foden

Subs: Carson, Sterling, Gundogan, Jesus, Zinchenko, Fernandinho, Delap, Mbete, McAtee

Manchester United XI: de Gea, Wan-Bissaka, Lindelof, Maguire, Telles, McTominay, Fred, Pogba, Fernandes, Sancho, Elanga

Subs: Henderson, Bailly, Dalot, Jones, Hannibal, Lingard, Mata, Matic, Rashford