We depart a frantic derby clash at Old Trafford to dive into six three o’clock kick-offs.

Fantasy managers will undoubtedly be fixated on Arsenal’s Emirates meeting with Southampton, as thousands head into the afternoon matches having invested in the likes of Alexis Sanchez, Mesut Ozil and Santi Cazorla.

Interestingly, only just over 4% of FPL managers have looked to Sanchez as their captain due to concerns over his pitch time.

Those fears have been founded with Arsene Wenger making the decision to bench the Chilean – disappointing the 245,000 who had introduced him to their squads heading into the Gameweek.

Arsenal’s rivals Spurs make a testing trip to take on Stoke City at the bet365 Stadium with Erik Lamela benched.

Meanwhile West Ham’s home tie with Watford will also be keenly anticipated by those who have shown faith in the Hammers backline and Dimitri Payet and Michail Antonio in attack. Both start against the Hornets.

Alvaro Negredo heads into his home clash with Crystal Palace with the backing of 32.5% of Fantasy Premier League managers, ensuring that the Riverside encounter is high on today’s agenda.

Finally, interest in Bournemouth’s clash with West Brom and Burnley’s tie with Hull City is likely to be limited to the pursuit of clean sheets. The Clarets’ Tom Heaton and the Baggies Gareth McAuley continue to grow their popularity over the international break – they’re owned by 7.8% and 22.4% of FPL managers respectively.