With the 2025 Africa Cup of Nations (AFCON) fast approaching, many of us will soon be faced with a few flagged stars in our Fantasy Premier League (FPL) squads.
Thankfully, weโll all see our free transfer allowance topped up to the maximum of five in advance of the tournament commencing, meaning there neednโt be a mad rush to ditch the affected players quite yet.
But when the time comes, could it pay dividends to make a short-term investment in some differential players who might step up to replace their departed teammates during AFCON?
We explore that very question below.
WHEN IS AFCON 2025?

First, a quick reminder of the state of play.
AFCON will take place between Sunday 21 December 2025 and Sunday 18 January 2026.
That covers Gameweeks 17 to 22 in FPL, with Gameweek 16 the point in time where weโll all be given five free transfers – regardless of how much we have saved leading up to that round of fixtures – to help us out.
Thatโs because clubs usually must release players a fortnight before continental competitions, meaning these international players may also miss Gameweek 16 unless any agreement is struck – possibly on a player-by-player basis – allowing them to arrive later.
Now, exiting in the group stage could mean players return as early as Gameweek 20, though it would be a quick turnaround for them to be involved.
However, anyone whose country makes it through to the knockout rounds could miss up to five Gameweeks, while making it to the semi-finals means theyโll miss six, as thereโs a third/fourth-place play-off to contest, too.
Ghana have missed out on qualifying for the first time in two decades, meaning FPL managers with the likes of Antoine Semenyo (ยฃ8.1m) and Mohammed Kudus (ยฃ6.5m) in their squads have fewer decisions to make this time.
Arsenal, Chelsea and Leeds United, meanwhile, are completely unaffected – but there will be a few notable absentees, whose replacements weโll now discuss.
LIVERPOOL

Heโs thus far faded considerably from last seasonโs dizzying FPL heights, but Mohamed Salah (ยฃ14.2m) has still started every Premier League game this term. Heโs only been subbed once before the 90th minute, too.
So when the Egyptian star is away for AFCON, who can replace him?
Federico Chiesa (ยฃ6.4m) is one option, though Arne Slot evidently doesnโt fancy him very much. Despite his own versatility and Liverpoolโs faltering attack, the Italian is yet to start a single match in 2025/26 aside from in the Carabao Cup.
What, then, about Jeremie Frimpong (ยฃ5.7m)?
The Dutch right-sider has endured an injury-hit start to life at Anfield following his summer arrival, and the time he has been available has been spent in rotation with Conor Bradley (ยฃ5.0m) and even Dominik Szoboszlai (ยฃ6.6m) at right-back.
However, in his career, the 24-year-old has actually started more games on the right side of midfield than any other position.
Frimpong has plenty of attacking experience from his prolific days as part of Xabi Alonsoโs Bayer Leverkusen, as well as with Celtic before that, and has even started there once ahead of Salah this season (albeit in Septemberโs ill-fated Champions League trip to Galatasaray).
If he recovers from his hamstring injury in time for Salahโs departure, heโd certainly offer more (much-needed) defensive cover on that side than its usual occupant while also having more license to get forward than he usually would as a right-back, offering an enticing FPL option for Liverpoolโs decent fixtures.
An alternative, though, is the 4-4-2 that Slot fielded for last monthโs win at Eintracht Frankfurt, a match where Salah was benched with Florian Wirtz (ยฃ8.0m) and Cody Gakpo (ยฃ7.5m) as the two wide men and a two-man frontline of Alexander Isak (ยฃ10.4m) and Hugo Ekitike (ยฃ8.6m).
MANCHESTER CITY

An ankle injury has kept Rayan Ait-Nouri (ยฃ5.7m) sidelined for much of his time as a Manchester City player so far. Heโs available again now, but is expected to head to AFCON with Algeria.
Thankfully for Pep Guardiola, Nico OโReilly (ยฃ5.0m) has excelled as a makeshift left-back, starting all but one Premier League match there since his first time in the XI back in Gameweek 4 and keeping five clean-sheets in that eight-game spell.
The 20-year-old Englishman earned his first defensive contribution (DefCon) points of the campaign during Gameweek 11โs resounding beat-down of Liverpool, too, with his assist in that game taking him to three attacking returns from his last three league starts.
Omar Marmoush (ยฃ8.3m), who will join Salah in representing Egypt, has also missed a chunk of this season so far, thanks to a knee injury.
Heโs yet to start since his return from the setback, though, and the form of Cityโs other attackers like Erling Haaland (ยฃ14.9m), Jeremy Doku (ยฃ6.4m), Rayan Cherki (ยฃ6.3m) and Phil Foden (ยฃ8.0m) means Marmoushโs absence for AFCON shouldnโt be too sorely felt.
MANCHESTER UNITED

More impactful departures are those of Bryan Mbeumo (ยฃ8.5m) and Amad Diallo (ยฃ6.3m) from Manchester United.
The two have formed an effective attacking partnership since Mbeumoโs arrival from Brentford, and whatever length of time they spend away with Cameroon and the Ivory Coast, respectively, will be a blow to Ruben Amorimโs side.
What it should do, though, is give Benjamin Sesko (ยฃ7.3m) more assured gametime up front, assuming the Slovenianโs knee issue picked up in Gameweek 11 isnโt too severe; if it is, perhaps wantaway forward Joshua Zirkzee (ยฃ5.8m) might finally get a look-in to help him secure a January move.
Less competition for the limited attacking spots in Amorimโs 3-4-2-1 should also mean Matheus Cunha (ยฃ7.9m) is a mainstay in the XI, while Mason Mount (ยฃ5.9m) may also benefit from Mbeumoโs absence to start as a No 10. The skipper Bruno Fernandes (ยฃ8.9m) could alternatively move into that role again, but Amorim seems to have more trust in Mount than he does in his central midfield replacements like Manuel Ugarte (ยฃ4.8m) or Kobbie Mainoo (ยฃ4.7m).
Unitedโs mixed bag of Gameweek 16-23 fixtures means there mightnโt be much interest in their defence, but itโs worth noting that Noussair Mazraoui (ยฃ4.9m) might also be away, representing Morocco.
That reduces Amorimโs options in the back three while also – combined with the absence of Amad – leaving Patrick Dorgu (ยฃ4.2m) and Diogo Dalot (ยฃ4.4m) as the likeliest wing-back options during AFCON.
NEWCASTLE UNITED

A knee injury has kept Yoane Wissa (ยฃ7.3m) from involvement in any Newcastle matches so far, and heโs likely to be called up by DR Congoโs national side if heโs recovered in time for AFCON.
That means Nick Woltemade (ยฃ7.4m) should face minimal competition up front for the Magpies into the New Year, which could see his FPL ownership spike given Eddie Howeโs side sit behind only Brentford on the Fixture Ticker between Gameweeks 16 and 23.
SUNDERLAND

High-flying Sunderland are set to lose several players during AFCON, with Chemsdine Talbi (ยฃ5.0m), Noah Sadiki (ยฃ5.0m), Simon Adingra (ยฃ5.1m), Bertrand Traore (ยฃ5.5m) and the currently injured Habib Diarra (ยฃ5.3m) all potential absentees given their respective countriesโ involvement.
That leaves Enzo Le Fee (ยฃ4.9m) – who could be on spot-kick duty, after his successful effort earlier this season – to carry the load alongside captain Granit Xhaka (ยฃ5.1m).
At the back, Reinildo (ยฃ4.0m) and Arthur Masuaku (ยฃ3.9m) will leave a hole at left-back, which could be filled either by Dennis Cirkin (ยฃ4.0m) or Trai Hume (ยฃ4.5m), if the latter switches sides.
CRYSTAL PALACE

Crystal Palace’s attack will be without Senegalโs Ismaila Sarr (ยฃ6.7m) and possibly the far less utilised Nigerian striker Christansus Uche (ยฃ5.5m).
That leaves the Eagles relatively thin up top in support of Jean-Philippe Mateta (ยฃ8.1m), so thereโs every chance we see Daichi Kamada (ยฃ5.0m) shifted further forward in midfield. The Japan international has taken up more of a central role with increased defensive duties lately, but Oliver Glasner has more options in the middle of the park to partner Adam Wharton (ยฃ5.0m) – like Will Hughes (ยฃ4.8m) and Jefferson Lerma (ยฃ4.9m) – and could therefore free up Kamada to swap some of his DefCon points (four in his last five outings) for more attacking returns (he has two assists this season). Youngster Justin Devenny (ยฃ4.3m) is another option here.
Yeremy Pino (ยฃ5.8m), the usual left-sided prong to Sarrโs right behind Mateta in Glasnerโs 3-4-2-1, could see more of Palaceโs attacking play go through him, while thereโs a chance Daniel Munoz (ยฃ5.7m) could be given even more license to roam forward to make up for Sarrโs loss.
Perhaps the most like-for-like Sarr replacement in the right wing/attacking midfield position is Romain Esse (ยฃ4.7m), but the 20-year-old has just one Premier League appearance under his belt this season. Given the Eagles have a few big tests during the AFCON window, itโs perhaps unlikely that Esse is thrown directly into the fray at that point.
If it isnโt him, and should Glasner prefer to keep Kamada in central midfield, another option – which may require a bit more of a tactical tweak – is Eddie Nketiah (ยฃ5.4m). The ex-Arsenal striker should be sufficiently recovered from his hamstring injury by the time AFCON rolls around, and could be deployed alongside Mateta to help replace some of the goal threat that the team will be lacking when Sarr is away.
FULHAM

Fulham sit pretty high on our Fixture Ticker between Gameweeks 16 and 23. Theyโve been in relatively poor form all season, the Cottagers, but fixtures against Burnley (a), Nottingham Forest (h) and West Ham United (a) could help turn their season around.
Marco Silva will be without Nigerian defensive stalwart Calvin Bassey (ยฃ4.5m) and his countryman, winger Alex Iwobi (ยฃ6.5m), for those games during AFCON.
At the back, Jorge Cuenca Barreno (ยฃ4.4m) is probably the likeliest man to step into the middle of the backline alongside Joachim Andersen (ยฃ4.5m), given the Spaniard started the one Premier League match this season that Bassey didnโt (Gameweek 8).
The player possibly most likely to benefit from Iwobiโs absence, meanwhile, is Kevin (ยฃ5.9m).
The Brazilian is most comfortable on the left-hand side, where Iwobi usually operates, and indeed started there in both Gameweeks 10 and 11, with his teammate playing elsewhere. AFCON could therefore offer the perfect opportunity for Fulhamโs club-record signing to shine.
BRENTFORD

Brentfordโs main loss during AFCON will be Dango Ouattara (ยฃ6.0m), who terrorised Newcastleโs backline in Gameweek 11 to earn his fourth attacking return of the season and his third in three Gameweeks (the other two came against Liverpool).
The Burkina Faso international has started five of the Beesโ last six Premier League matches, on the right of Keith Andrewsโs 4-2-3-1, but how have they lined up without him?
Well, thatโs largely been as a 5-3-2 with FPL midfielder Kevin Schade (ยฃ7.0m) alongside in-form frontman Igor Thiago (ยฃ6.3m), so itโs possible Andrews just reverts to this when Ouattara is away – making Schade an appealing out-of-position option given Brentford sit top of our Fixture Ticker between Gameweeks 16 and 23, aided by their early double header against Leeds (h) and Wolverhampton Wanderers (a).
That system has usually been deployed against tougher opponents, though, so will Brentford stick to their 4-2-3-1? Mikkel Damsgaard (ยฃ5.8m) isnโt particularly likely to be shifted from his central playmaking role, while Fabio Carvalho (ยฃ4.8m) is one possible replacement out wide, but heโs failed to impress thus far in west London, so it might be a bit of a leap.
The versatile Keane Lewis-Potter (ยฃ4.9m), a defender in FPL, started on the right wing in Gameweek 1, and could be another option there. So too could teenage winger Gustavo Nunes (ยฃ4.9m), although as of Gameweek 11, weโve yet to see the Brazilian in a Brentford first-team shirt, largely due to a hamstring injury.
In summary, then, Ouattaraโs absence means Schade probably remains the stand-out Bees attacker not named Thiago, but Carvalho, Lewis-Potter or Nunes could be great short-term punts if we get any early indication as to which of the trio might start in Gameweek 16.
EVERTON

Everton will be missing Senegalese attacker Iliman Ndiaye (ยฃ6.5m).
The Toffeesโ top goal-scorer, Ndiaye will leave a hole on the right of David Moyesโs frontline when he leaves for AFCON. Dwight McNeil (ยฃ5.5m) has experience on his side, while Carlos Alcaraz (ยฃ5.2m) started Gameweek 1 on that flank and has been a bit-part player since then.
Surely, though, this is the best chance young Tyler Dibling (ยฃ5.4m) will get to shine this season?
A coveted talent when he signed from Southampton this summer, Diblingโs only Premier League start of the campaign so far came on the right wing against Crystal Palace in Gameweek 7, when usual No 10 Kiernan Dewsbury-Hall (ยฃ4.9m) was suspended and Ndiaye shifted across into the middle. The 19-year-old was hooked at half-time with Everton trailing, Alcaraz thrown on in his place, and weโve only seen him once – as a stoppage-time sub the following week – since then.
But with Jack Grealish (ยฃ6.8m) crafting chances on the opposite wing and Dewsbury-Hall doing the same from his central post, Dibling – if Moyes hands him the reigns on the right – could make the most of some appealing Everton fixtures during AFCON, especially if Senegal go far in the competition and keep Ndiaye away for an extended period of time.
The Toffees will also be without Senegal midfielder Idrissa Gueye (ยฃ5.4m); itโs possible Moyes turns to someone like Alcaraz in the middle of the park instead, with Tim Iroegbunam (ยฃ4.9m) or Merlin Rohl (ยฃ5.0m) also options – but ones with limited FPL appeal – alongside James Garner (ยฃ5.0m) there.
ASTON VILLA

Aston Villa got off to a rocky start in 2025/26 but have since seemed to get back on track. Unai Emery has given a decent chunk of minutes to Evann Guessand (ยฃ6.2m) throughout it all despite the summer signing being yet to register an attacking return in 10 Premier League appearances (five of them starts).
Now, though, the Ivory Coast international is expected to jet off with his country for AFCON, which could boost the FPL appeal of a certain Donyell Malen (ยฃ5.1m).
The Dutchman has struggled for a regular place in Unai Emeryโs XI ever since he arrived in the Midlands in January, kept out of the side by a combination of last seasonโs loanees Marcus Rashford and Marcos Asensio plus first-teamers like Ollie Watkins (ยฃ8.5m) and Morgan Rogers (ยฃ6.8m), and now Guessand.
He only has three league starts to his name this term, but Malen also has three goals after his successful effort as a substitute in Gameweek 11โs rout of Bournemouth. An option on the right in Guessandโs absence, as well as a second striker – where he excelled with a brace versus Burnley – and even as a potential line leader, should Watkinsโs form continue to suffer and Emery elect to tweak some more, Malen presents a potentially enticing option at his lowly price given Villa have a few nice fixtures during AFCON.
Though perhaps less of a direct beneficiary of Guessandโs absence, Emiliano Buendia (ยฃ5.3m) is another cheap Villa attacker who has done incredibly well from limited gametime this season and could see his minutes boosted with the temporary dip in competition for the teamโs attacking spots.
WEST HAM UNITED

West Ham, who have improved under Nuno Espirito Santo to win back-to-back Premier League games for the first time, will lose full-backs Aaron Wan-Bissaka (ยฃ4.3m) and El Hadji Malick Diouf (ยฃ4.3m) to AFCON with DR Congo and Senegal, respectively.
The main door that opens is for Kyle Walkers-Peters (ยฃ4.3m), who came off the bench to nick what proved to be the winner against Burnley in Gameweek 11.
With some decent fixtures over the AFCON period, Walker-Peters could be set for a prolonged run in the Hammersโ XI at just the right time to spark FPL investment.
OTHERS

Elsewhere, here are a few other players who could be missing from their respective teams, along with who could replace themโฆ
| Team | Players at AFCON | Who could replace them |
|---|---|---|
| Burnley | Lyle Foster (South Africa), Axel Tuanzebe (DR Congo), Hannibal Mejbri (Tunisia) | Lyle Foster (ยฃ5.0m) appears to have lost his starting striker spot to Zian Flemming (ยฃ5.3m) anyway, and Hannibal Mejbri (ยฃ4.8m) – despite recently registering two assists in the space of three substitute appearances – hasnโt started since Gameweek 3. That leaves Axel Tuanzebe (ยฃ3.9m) as the man Scott Parker will need to most urgently find a replacement for. Luckily for him, Swedish centre-back Hjalmar Ekdal (ยฃ4.0m) is ready to stand in, having started Burnleyโs first six Premier League matches this season before giving way to Tuanzebe. With that being said, the Clarets likely wonโt be that high on too many wishlists when it comes to players to bring in as AFCON cover, with their budget-friendly prices probably their most appealing feature. |
| Brighton | Carlos Baleba (Cameroon) | Similarly, Carlos Baleba (ยฃ4.7m) isnโt much of an FPL asset and consequently sits in few squads. Brighton also have so many midfield options, and rotate so regularly, that itโs a little hard to ascertain who Fabian Hurzeler will pick in the Cameroon starโs absence. For the one Premier League match Baleba missed this season, it was James Milner (ยฃ4.9m) and Jack Hinshelwood (ยฃ5.1m) starting as the Seagullsโ defensive midfielders; both men are currently injured. Hurzeler could give a chance to a youngster, play a defender out of position or put Mats Wieffer (ยฃ4.9m) back in the middle of the park. |
| Bournemouth | Amine Adli (Morocco) | Morocco international Amine Adli (ยฃ5.4m) has only started one Premier League match so far for Bournemouth, who therefore shouldnโt feel the effects of AFCON too strongly at all – especially given Semenyo is sticking around. What Adliโs unavailability could do is give Scotsmen Ryan Christie (ยฃ5.0m) or Ben Gannon-Doak (ยฃ4.9m) more of a chance to get on the field, though David Brooks (ยฃ5.0m) probably remains ahead of them in the pecking order when it comes to Andoni Iraolaโs squad options in midfield. Could it help Eli Junior Kroupi (ยฃ4.6m) get more minutes? Itโs unlikely to directly, with his main competition being Evanilson (ยฃ7.0m), but again thereโs one less person on the bench. |
| Nottingham Forest | Ola Aina (Nigeria) | Ola Aina (ยฃ4.7m) is only expected to return from his hamstring injury shortly before AFCON begins, so he may not even be called up by Nigeria. If he is, though, itโll be Nicolo Savona (ยฃ4.5m) who continues at full-back. |
| Tottenham Hotspur | Pape Matarr Sarr (Senegal), Yves Bissouma (Mali) | Tottenham could lose Pape Matarr Sarr (ยฃ4.8m) and Yves Bissouma (ยฃ5.2m) to Senegal and Mali, respectively. The latter hasnโt featured all season for various reasons, most recently an ankle injury, but Sarr – having lost his spot in Thomas Frankโs XI for a time has worked his way back into the starting line-up of late after registering his fourth attacking return of the Premier League campaign. Less competition in the middle of the park is good news for all of Joao Palhinha (ยฃ5.5m), Rodrigo Bentancur (ยฃ5.3m) and Lucas Bergvall (ยฃ5.4m), and potentially Xavi Simons (ยฃ6.7m), too. Spurs have a few decent fixtures during AFCON – largely at the beginning and end – but do also have Champions League football to contend with, meaning rotation may still be rife over the Christmas period. |
| Wolves | Emmanuel Agbadou (Ivory Coast), Jackson Tchatchoua (Cameroon), Marshall Munetsi (Zimbabwe) | Does anyone want any Wolves players anyway? Probably not, at this point. As well as their terrible form, which has them comfortably last in the Premier League, they also sit bottom of our Fixture Ticker between Gameweeks 16 and 23; ouch. Still, we should let you know that Emmanuel Agbadou (ยฃ4.3m) and Jackson Tchatchoua (ยฃ4.5m) – who have each been in and out of the Old Goldโs backline this season – could be called up for AFCON by the Ivory Coast and Cameroon, respectively, which could mean more secure starts for the rest of the group (whether thatโs worth anything to us in FPL terms is up to you). Wolves will also be without their highest-scoring FPL midfielder, Marshall Munetsi (ยฃ5.4m). Will anyone step up to replace him? That’s unclear, but Jhon Arias (ยฃ5.1m) and Jean-Ricner Bellegarde (ยฃ5.2m) have each been given some attacking license at times, while Hwang Hee-chan (ยฃ5.8m) started up top in a two-man frontline in Gameweek 11 (albeit to no avail). |


