Six Premier League matches get underway at 15:00 GMT today, with Liverpool and Manchester City among the dozen teams in action.
Sergio Aguero (£12.1m) has been named in Pep Guardiola’s starting XI for the first time in the league since Gameweek 8.
Just shy of 300,000 Fantasy managers sold the Argentina international in the lead-up to Gameweek 11.
Raheem Sterling (£12.1m), Kevin De Bruyne (£10.2m) and David Silva (£7.7m) also start.
Nicolas Otamendi (£5.4m), Riyad Mahrez (£8.5m), Benjamin Mendy (£6.0m) and Joao Cancelo (£5.3m) are the victims of Guardiola’s rotation roulette, however, with all four benched.
The Saints have made three changes from last Friday’s hammering by Leicester, with a switch of goalkeepers among the alterations.
Mohamed Salah (£12.4m) is fit to start and joins Roberto Firmino (£9.5m) and Sadio Mane (£11.9m) in a familiar-looking front three.
The Reds’ back four is unchanged, too.
Fabinho (£5.5m), who is on four yellow cards, is benched, with perhaps one eye on next weekend’s clash with Manchester City.
Jack Grealish (£5.9m) has not recovered a calf injury and misses out, with Anwar El Ghazi (£5.5m) replacing him.
Unai Emery has recalled Mesut Ozil (£7.2m) to his starting XI for the first time in the Premier League since Gameweek 5.
Nicolas Pepe (£9.3m) makes way for the German, while Granit Xhaka (£5.3m) is excluded from the matchday squad as expected.
Nuno Espirito Santo sticks with the side that started Wolves’ 1-1 draw at Newcastle last Sunday.
Todd Cantwell (£4.8m) has been benched for the first time this season, with Onel Hernandez (£5.3m) taking his place.
Graham Potter has named the same 11 players who started against Everton last Saturday, meanwhile.
West Ham are also unchanged from last weekend, while Steve Bruce recalls Isaac Hayden (£4.4m) and Jonjo Shelvey (£5.0m) for the Longstaff brothers.
There is only one change to the starting XIs at Bramall Lane, with Lys Mousset (£4.9m) replacing Callum Robinson (£5.3m) for the hosts.
Chris Wood (£6.2m) misses out again for Burnley.
Arsenal XI: Leno, Chambers, Papastathopoulos, Luiz, Tierney, Guendouzi, Torreira, Ozil, Ceballos, Lacazette, Aubameyang.
Wolves XI: Patricio, Dendoncker, Coady, Saiss, Doherty, Moutinho, Neves, Jonny, Traore, Jimenez, Jota.
Aston Villa XI: Heaton, Guilbert, Engels, Mings, Targett, McGinn, Nakamba, Douglas Luiz, El Ghazi, Trezeguet, Wesley.
Liverpool XI: Alisson, Alexander-Arnold, Lovren, van Dijk, Robertson, Henderson, Wijnaldum, Lallana, Salah, Firmino, Mané.
Brighton XI: Ryan, Montoya, Webster, Dunk, Burn, Gross, Pröpper, Stephens, Alzate, Maupay, Connolly.
Norwich XI: Krul, Lewis, Godfrey, Tettey, Aarons, Trybull, Buendia, McLean, Stiepermann, Hernández, Pukki.
Man City XI: Ederson, Walker, Stones, Fernandinho, Angelino, Gundogan, Silva, De Bruyne, Bernardo, Sterling, Aguero.
Southampton XI: McCarthy, Valery, Bednarek, Stephens, Vestergaard, Hojbjerg, Ward-Prowse, Romeu, Armstrong, Ings, Redmond.
Sheffield United XI: Henderson, Basham, O’Connell, Egan, Baldock, Fleck, Lundstram, Norwood, Stevens, McGoldrick, Mousset.
Burnley XI: Pope, Lowton, Tarkowski, Mee, Pieters, Hendrick, Westwood, Cork, McNeil, Rodriguez, Barnes.
West Ham XI: Roberto, Zabaleta, Balbuena, Diop, Cresswell, Rice, Yarmolenko, Noble, Snodgrass, Felipe Anderson, Haller.
Newcastle XI: Dubravka, Yedlin, Fernandez, Lascelles, Clark, Willems, Almiron, Hayden, Shelvey, Saint-Maximin, Joelinton.
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