The bottom two clubs in the Premier League face one another at St. Mary’s in the evening kick-off, as Southampton entertain Watford.
Kick-off on the south coast is at 17:30 GMT.
Ralph Hasenhuttl makes one enforced change to the Southampton side that drew 2-2 with Arsenal last weekend.
Moussa Djenepo is promoted to the starting XI in place of Stuart Armstrong, who is ruled out with a hamstring problem.
Sofiane Boufal makes the bench, having stubbed his toe in midweek.
Quique Sanchez Flores has made two changes to the Watford team that lost 3-0 at home to Burnley.
Left-back Adam Masina looks like he is filling in at centre-half as he replaces the injured Craig Dawson in defence, while Ismaila Sarr comes in for striker Andre Gray up top.
Roberto Pereyra has overcome a thigh strain but is only among the substitutes, as is Troy Deeney.
Not a single player on show this evening can boast a double-digit ownership.
Danny Ings is the most-owned player involved in tonight’s game, sitting in 6.5% of Fantasy Premier League squads.
Ings has scored five goals in the last seven Gameweeks, picking up nine bonus points along the way.
The Saints haven’t won since September, however.
Watford have kept clean sheets in three of the last six Gameweeks, meanwhile.
Southampton XI: McCarthy, Cedric, Stephens, Bednarek, Bertrand, Djenepo, Ward-Prowse, Hojbjerg, Redmond, Obafemi, Ings.
Watford XI: Foster, Femenia, Mariappa, Masina, Cathcart, Holebas, Doucoure, Capoue, Hughes, Deulofeu, Sarr.