Pep Guardiola has frustrated Fantasy Premier League managers once again by leaving Riyad Mahrez (£8.5m) and Gabriel Jesus (£9.5m) on the bench.
That move sees Raheem Sterling (£11.8m) and Bernardo Silva (£7.8m) come back into the side for the visit of Crystal Palace.
There is better news for owners of Kevin de Bruyne (£10.7m) and Sergio Aguero (£11.8m) who both keep their places from the win at Aston Villa.
Owners of Martin Kelly (£4.4m) have some reasons to be encouraged, even if they are benching him for the Eagles’ trip to the Etihad Stadium.
Despite Joel Ward‘s (£4.3m) return to fitness, the budget defender starts at right-back while Cenk Tosun (£5.7m) is set to make his Palace debut, named up-front alongside Jordan Ayew (£5.0m).
It is Moise Kean (£6.4m) who replaces the injured Richarlison (£8.1m) for Everton, while Djibril Sidibé (£5.4m) is benched in favour of Seamus Coleman (£5.3m).
Jack Grealish (£6.5m) looks set for another outing as a centre-forward for Aston Villa as Dean Smith lines up in a 3-4-3 formation, with the midfielder at the apex.
There is a return for Matt Targett (£4.4m), who looks to operating as a left wing-back in front of a back-three.
Opponents Brighton have gone with a front-three of Leandro Trossard (£5.8m), Neal Maupay (£5.9m) and Aaron Connolly (£4.4m).
Despite suggestions of rotation at Southampton, Danny Ings (£6.9m) holds onto his starting berth against Wolves.
Mikel Arteta is forced into a change at the back for Arsenal, Sokratis Papastathopoulos (£4.9m) out with illness. That sees Shkodran Mustafi (£5.2m) replace him at centre-back.
Meanwhile, Ainsley Maitland-Niles (£4.6m) holds onto his right-back berth although Hector Bellerín (£5.4m) is back on the bench.
Gabriel Martinelli (£4.5m) comes in for the suspended Pierre-Emerick Aubameyang (£10.7m).
Opponents Sheffield United are without David McGoldrick (£5.4m) who has suffered a minor foot injury, which means Lys Mousset (£4.7m) and Oli McBurnie (£5.7m) lead the line, supported by key midfielder John Lundstram (£5.1m).
Norwich have handed an immediate debut to new signing Duda (£5.0m) while there are starts in their attack for Todd Cantwell (£4.9m) and Teemu Pukki (£6.5m).
Bournemouth have lined-up in a 4-3-3 formation with Ryan Fraser (£6.9m) and Harry Wilson (£5.9m) either side of Callum Wilson (£7.4m).
Arsenal XI: Leno; Maitland-Niles, Mustafi, D Luiz, Saka; Torreira, Xhaka, Ozil; Pepe, Martinelli, Lacazette.
Sheffield United XI: Henderson; Basham, Egan, O’Connell; Baldock, Lundstram, Norwood, Fleck, Stevens; McBurnie, Mousset.
Brighton XI: Ryan; Alzate, Dunk, Webster, Bernardo; Mooy, Stephens, Propper; Trossard, Maupay, Connolly.
Aston Villa XI: Reina; Konsa, Mings, Hause; Guilbert, Drinkwater, Nakamba, Targett; Trezeguet, Grealish, El Ghazi
Manchester City XI: Ederson; Mendy, Fernandinho, Stones, Cancelo; D Silva, de Bruyne, Gundogan; Sterling, Aguero, B Silva
Crystal Palace XI: Guaita; Riedewald, Cahill, Tomkins, Kelly; Zaha, Kouyaté, McCarthy, McArthur; Ayew, Tosun.
Norwich XI: Krul; Byram, Zimmermann, Godfrey, Aarons; Tettey, McLean; Duda, Cantwell, Buendía; Pukki.
Bournemouth XI: Ramsdale; Rico, Aké, S Cook, A Smith; Billing, Gosling, Lerma; Fraser, C Wilson, H Wilson.
Southampton XI: McCarthy; Bertrand, Bednarek, J Stephens, Cédric; Redmond, Ward-Prowse, Højbjerg, Armstrong; S Long, Ings.
Wolves XI: Patrício; Saïss, Coady, Dendoncker; Jonny, Neves, Moutinho, Doherty; Neto, Jiménez, Traoré.
West Ham XI: Randolph; Cresswell, Diop, Ogbonna, Zabaleta; Rice, Noble; Snodgrass, Lanzini, Fornals; Haller.
Everton XI: Pickford; Digne, Holgate, Mina, Coleman; Bernard, Delph, T Davies, Walcott; Kean, Calvert-Lewin