On-loan Brighton goalkeeper Mat Ryan (£4.2m) makes his Arsenal debut in Gameweek 23.
A hip problem ruled the stopper out for Gameweek 22 but Ryan returned to full training on Friday.
Bernd Leno (£5.0m) is serving a one-match suspension after being sent off as Arsenal lost 2-1 at Wolves on Tuesday. David Luiz (£5.4m) is in the same boat after his red card at Molineux.
Having only returned to the Arsenal matchday squad in GW22 following a personal issue, Pierre-Emerick Aubameyang (£11.3m) remains on the bench as Pepe (£7.6m) starts again. On that selection call, Mikel Arteta said:
It’s been a really difficult decision, as you can imagine. I felt that the players that played against Wolves, the way they played – they deserve another chance today and that’s why I stick with them.
Pepe joins Bukayo Saka (£5.4m), Emile Smith Rowe (£4.4m), and Alexandre Lacazette (£8.4m) in Arteta’s four-pronged attack.
With Kieran Tierney (£5.3m) still sidelined, Cedric (£4.6m) continues at left-back while Gabriel (£5.0m) slots in for David Luiz. On the Scottish full-back, Arteta said on Friday:
“We are trying to manage him in the best possible way and find every possibility to give him the best chance to be fit as soon as possible. Kieran is a player that really pushes himself and he has to be able to perform physically at his best because he cannot help himself. Even in training he can’t help himself.”
Asked whether the left-back’s injury has to be managed carefully:
“No, it’s a different injury in this case.”
For Aston Villa, Douglas Luiz (£4.9m) drops to the bench as Marvelous Nakamba (£4.3m) is drafted into midfield.
Bertrand Traoré (£5.9m) also returns to Dean Smith’s starting XI, after Anwar El Ghazi (£5.5m) earned a rare start on Wednesday as the Villans were turned over by West Ham.
Speaking to BT Sport ahead of kick off, Smith explained:
Just freshening it up. I rested Betrand on Wednesday. It’s been a lot of games; I think it’s our sixth game in 18 days.
Likewise with Douglas Luiz. He’s done OK but he’s played pretty much every minute so it was time to put Nakamba in.
Emi Martinez (£5.2m) banked four points in that midweek defeat, despite conceding three goals. He lines up behind the usual back four of Matt Targett (£4.8m), Tyrone Mings (£5.4m), Ezri Konsa (£4.6m) and Matty Cash (£5.0m).
Traoré rejoins Ross Barkley (£5.9m) and Jack Grealish (£7.8m) in attacking midfield, with Ollie Watkins (£6.3m) leading the Villa line.
On that West Ham loss, Smith said in his pre-Arsenal press conference on Friday:
The message was they’ve dropped below their standards. We’ve had some very high standards this season already and we keep speaking to the players, if we want to be a top team then we have to keep playing to those standards.
For me, there were too many six out of 10s on Wednesday night and if you drop to that level then you’re going to get beat. We found that out. The lads understand that as well and they know what they have to do to put it right.
On defensive mistakes against the Hammers, Smith added:
After the Burnley game, I only showed (the players) the set-piece goal, which I thought was really poor defending from ourselves. After the West Ham game, our debrief was all three goals, as they were really poor defensively.
I haven’t had cause to do that because we’ve set really high standards this season and I thought we dropped off it. It was the first time I thought we looked mentally tired more than anything, certainly there’s nothing in the numbers to suggest fatigue in any way, but it was the fifth game in 14 days, we’ve got our sixth game on Saturday in 18 days.
The lads have to make sure they’re ready for each game because it’s a tough league and can be punishing if you’re not right.
Aston Villa XI (4-2-3-1): Martinez; Targett, Mings, Konsa, Cash; McGinn, Luiz; Grealish, Barkley, B Traoré; Watkins.
Arsenal XI (4-2-3-1): Ryan; Cedric, Gabriel, Holding, Bellerin; Xhaka, Partey; Pepe, Smith Rowe, Saka; Lacazette.