Pep Guardiola has left Sergio Aguero (£11.5m) out of Manchester City’s matchday squad to face Bournemouth entirely.
That is because he has a minor injury that he does not want to risk worsening.
“He has a muscular disturbance. He is not I believe fit. It would be risky (to play him) the doctors and physios tell me. We don’t want to take that risk.” – Pep Guardiola
It is a no-show that will heavily effect the outcome of Fantasy Premier League Gameweek 14 with the Argentinian striker a strong captain candidate.
Gabriel Jesus (£10.1m) starts up front in his place while Raheem Sterling (£11.4m) keeps his place in the starting XI.
David Silva (£8.7m) left on the bench as Fernandinho (£5.4m), Ilkay Gundogan (£5.4m) and Bernardo Silva (£7.5m) all started in midfield, with Leroy Sané (£9.3m) operating on the left.
Meanwhile, John Stones (£5.3m) missed out at the expense of Nicolas Otamendi (£6.1m) again and Oleksandr Zinchenko (£4.8m) started at left-back in place of Fabian Delph (£5.3m).
Opponents Bournemouth dropped a surprise of their own with David Brooks (£5.1m) left on the bench.
Crystal Palace named an unchanged side from the one that drew 0-0 at Manchester United while Johann Berg Gudmundsson (£5.9m) returned to the Burnley line-up and James Tarkowski (£4.7m) is back from injury on the bench.
Huddersfield lined-up in their favoured 3-5-1-1 formation while Brighton have left Glenn Murray (£6.7m) on the bench.
Jamie Vardy (£8.9m) returns to the Leicester City side while James Maddison (£6.8m) keeps his place despite being sent off in Gameweek 13. His one-match suspension was served in the League Cup midweek.
Isaac Success (£4.6m) is back in the Watford line-up with Troy Deeney (£5.9m) going back to the bench. The Nigerian international starts up front with Gerard Deulofeu (£5.4m) again.
“Today we feel Isaac and Gerard in the beginning may be better but we know Troy and Andre will be ready if we need them.” – Javi Gracia
Jose Holebas (£4.7m) also comes back in after missing Gameweek 13 with a calf injury.
Finally, Jamaal Lascelles (£4.7m) is fit enough for a return only to the Newcastle bench, while Javier Manquillo (£4.4m) starts in place of Ciaran Clark (£4.5m), who is also among the substitutes.
Their opponents West Ham line-up with both Marko Arnautovic (£7.1m) and Javier ‘Chicharito’ Hernandez (£6.2m) as well as Andy Carroll (£5.4m) back on the bench.
Robert Snodgrass (£5.3m) makes an immediate return from suspension but Grady Diangana (£4.5m) is not even in the matchday squad.
Crystal Palace XI: Hennessey; Wan-Bissaka, Tomkins, Sakho, van Aanholt; McArthur, Milivojevic, Kouyaté, Meyer; Townsend, Zaha.
Burnley XI: Hart; Lowton, Long, Mee, Taylor; Lennon, Defour, Cork, Johann Gudmundsson; Hendrick; Wood.
Huddersfield Town XI: Lössl; Zanka, Schindler, Kongolo; Hadergjonaj, Mooy, Hogg, Billing, Durm; Pritchard; Mounie.
Brighton XI: Ryan; Bruno, Duffy, Dunk, Bernardo; Pröpper, Bissouma; March, Groß, Izquierdo; Andone.
Leicester City XI: Schmeichel; Ricardo Pereira, Morgan, Evans, Chilwell; Mendy, Ndidi; Gray, Maddison, Albrighton; Vardy.
Watford XI: Foster; Kiko Femenía, Mariappa, Cathcart, Holebas; Doucouré, Capoue; Hughes, Pereyra; Deulofeu, Success.
Manchester City XI: Ederson, Danilo, Laporte, Otamendi, Zinchenko, Fernandinho, Gundogan, Bernardo, Sané, Sterling, Jesus
Bournemouth XI: Begovic, Daniels, Aké, Francis, Cook, Mings, Surman, Cook, Fraser, Wilson, King
Newcastle XI: Dubravka; Yedlin, Federico Fernández, Schär, Manquillo; Ritchie, Ki, Diamé, Kenedy; Ayoze Pérez; Rondón.
West Ham XI: Fabianski; Zabaleta, Balbuena, Diop, Cresswell; Felipe Anderson, Noble, Rice, Snodgrass; Chicharito, Arnautovic.
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