Gameweek 20 kicks off at 15:00 GMT today as five Premier League matches take place, including Spurs v Wolves and Brighton v Everton.
Christian Eriksen, Son Heung-min and Harry Kane are joined by Dele Alli in the Spurs attack, while Kieran Trippier, Ben Davies and Davinson Sanchez return to the home defence.
Wolves meanwhile have made three changes in the midfield/forward positions, with Ruben Neves and Ivan Cavaleiro recalled and Leander Dendoncker making his first Premier League start.
Gylfi Sigurdsson and Dominic Calvert-Lewin drop to the bench for Everton’s trip to Brighton, as Richarlison is recalled up front.
Marco Silva is once again deploying a wing-back system after their 5-1 success at Turf Moor on Boxing Day.
Brighton recall Florin Andone in attack at the expense of Glenn Murray, while David Button is the £4.0m-rated goalkeeper given the nod to deputise for Mathew Ryan.
Jose Holebas, Abdoulaye Doucoure and Troy Deeney are among the substitutes as Javi Gracia makes six changes for the visit of Newcastle, who recall Christian Atsu, Ayoze Perez and Salomon Rondon.
Tom Cairney and Luciano Vietto replace Aboubakar Kamara and Andre Schurrle as Claudio Ranieri again rolls out a 3-4-3. Chris Lowe returns for Huddersfield, meanwhile.
Jamie Vardy and James Maddison both start for Leicester this afternoon, with the Foxes entertaining a Cardiff side who welcome back Callum Paterson from injury up front.
Brighton and Hove Albion XI (4-3-3): Button, Bernardo, Dunk, Duffy, Montoya, Stephens, Propper, Gross, March, Andone, Locadia.
Everton XI (3-4-3): Pickford, Zouma, Keane, Mina, Digne, Gomes, Gueye, Coleman, Bernard, Richarlison, Walcott.
Fulham XI (4-3-3): Rico, Odoi, Mawson, Ream, Christie, Chambers, Seri, Bryan, Cairney, Mitrovic, Vietto.
Huddersfield Town XI (3-5-1-1): Lossl, Zanka, Schindler, Kongolo, Durm, Hadergjonaj, Hogg, Billing, Lowe, Pritchard, Mounie.
Leicester City XI (4-2-3-1): Schmeichel, Pereira, Soyuncu, Maguire, Chilwell, Mendy, Ndidi, Albrighton, Maddison, Gray, Vardy
Cardiff City XI (4-5-1): Etheridge, Ecuele Manga, Morrison, Bamba, Cunningham, Gunnarsson, Hoilett, Camarasa, Arter, Murphy, Paterson.
Tottenham Hotspur XI (4-2-3-1): Lloris, Trippier, Alderweireld, Sanchez, Davies, Sissoko, Winks, Eriksen, Dele, Son, Kane.
Wolverhampton Wanderers XI (3-4-3): Rui Patricio, Coady, Boly, Bennett, Doherty, Neves, Dendoncker, Jonny, Cavaleiro, Jimenez, Traore.
Watford XI (4-4-2): Foster, Janmaat, Cathcart, Mariappa, Masina, Hughes, Quina, Capoue, Pereyra, Deulofeu, Success.
Newcastle United XI (3-4-2-1): Dubravka, Fernandez, Lascelles, Dummett, Ritchie, Diame, Hayden, Yedlin, Atsu, Perez, Rondon.
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5 years, 5 months agoTime to give Kane a rest Poch.. Bring the Lion King on.