The penultimate match of Gameweek 28 sees third played fifth in the race for UEFA Champions League qualification.
Kick-off at Old Trafford is at 19:15 GMT.
The most-captained player of Gameweek 28, Bruno Fernandes (£11.5m), features in this clash.
Those Fantasy managers who handed the armband to – or perhaps vice-captained, after yesterday’s Manchester City no-shows – the Portuguese midfielder have a chance to steal a march on their rivals following blanks for the likes of Harry Kane (£11.4m) and Son Heung-min (£9.6m) in the earlier kick-off.
Ole Gunnar Solskjaer has made just the one change from the United side that triumphed in the Manchester derby.
It’s an enforced one at that, with Mason Greenwood (£7.0m) in for the injured Anthony Martial (£8.6m) up top.
Martial and Edinson Cavani (£7.8m) aren’t involved in the matchday squad and neither is David de Gea (£5.3m), whose spell in quarantine will end after today’s game.
Marcus Rashford (£9.5m) is fit to feature, however.
David Moyes has made three alterations from the side that beat Leeds United 2-0 on Monday.
Mark Noble (£4.5m) makes his first competitive start since West Ham last played at Old Trafford in the FA Cup at the beginning of February.
Jarrod Bowen (£5.9m) and Ben Johnson (£3.9m) also come into the side.
Said Benrahma (£6.0m) is benched, Pablo Fornals (£5.9m) misses out with a minor muscle strain and Jesse Lingard (£6.1m) is ineligible to feature against his parent club.
GAMEWEEK 28 SO FAR…
The north London derby was a dismal watch for most Fantasy managers with Tottenham Hotspur representation in their squads.
Son Heung-min (£9.6m) limped off with an injury, Gareth Bale (£9.5m) failed to make it to even the 60-minute mark and Harry Kane (£11.4m) was denied by an offside flag and a goalpost as Spurs’ three popular attacking assets accumulated just four points between them.
On Son’s issue, Jose Mourinho said:
That’s football. I don’t know how long it is. It’s muscular. Muscular is always not easy. He’s a guy that normally recovers very, very well from any kind of injury.
That’s an accumulation of matches. In the Europa League the other day, I gave him 30 minutes rest… but 60 is still 60. And when you are in so many competitions, some players they have more minutes than others, which is normal. It’s something that can happen.
Bale was hooked because of what his manager described was a lack of “intensity”, meanwhile.
Spurs barely deserved the lead given to them by Erik Lamela‘s (£5.7m) rabona, with another effort on goal not arriving until the 70th minute.
After a quiet game, Kane belatedly found the net with a header that was flagged for offside before seeing a late free-kick smash against the hosts’ goalframe.
Arsenal turned the game around with a deflected effort from Martin Odegaard (£5.9m) and an Alexandre Lacazette (£8.1m) penalty.
Owners of the Gunners’ two most-popular assets were as much out of luck as those with Spurs’ in-demand players.
Bukayo Saka (£5.3m) was withdrawn at half-time with a hamstring injury, while Pierre-Emerick Aubameyang (£11.4m) was an unused substitute for disciplinary reasons.
Their manager explained:
We don’t know [about Saka]. He was feeling his hamstring.
[Aubameyang] was going to start the game. We had a disciplinary issue, we have drawn the line and we move on. We have a process that we have to respect for every game, and that’s it.
We deal with the situation on the day. That’s been done, now we move on.
Manchester United XI: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, McTominay, Greenwood, Fernandes, James, Rashford.
West Ham United XI: Fabianski, Coufal, Dawson, Diop, Cresswell, Rice, Soucek, Johnson, Noble, Bowen, Antonio.
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3 years, 1 month ago36 with Salah(c) left, might as well count it as 40