The final two matches of Gameweek 12 kick off simultaneously at 16:30 GMT, with the Manchester derby at the Etihad the stand-out fixture.
Arsenal take on Wolves at the Emirates in the other tea-time game.
Manchester City have made just one change from the side that beat Southampton last weekend, with Riyad Mahrez replacing Leroy Sane.
That alteration will likely see Raheem Sterling move over to the left flank, as he had done in the Champions League in midweek.
Sergio Aguero and Benjamin Mendy return to the City starting XI after being rested for that win over Shakhtar.
The injured Paul Pogba misses out altogether for United, while Romelu Lukaku is fit enough for a place on the bench after a return to training on Friday.
Alexis Sanchez drops out of the United line-up, meanwhile, with Marcus Rashford set to lead the attack.
Marouane Fellaini returns to a defensive-looking central midfield alongside Ander Herrera and Nemanja Matic.
In north London, Unai Emery has made one change from the side that drew with Liverpool: Alex Iwobi replacing Henrikh Mkhitaryan on the right flank.
Nuno Espirito Santo’s side remains unchanged, though Diogo Jota has recovered from injury to take his place among the Wolves substitutes.
Manchester City XI: Ederson, Walker, Stones, Laporte, Mendy, Fernandinho, Silva, Mahrez, Bernardo, Sterling, Aguero.
Manchester United XI: De Gea, Young, Lindelof, Smalling, Shaw, Matic, Herrera, Fellaini, Lingard, Rashford, Martial.
Arsenal XI: Leno, Bellerin, Mustafi, Holding, Kolasinac, Torreira, Xhaka, Iwobi, Ozil, Aubameyang, Lacazette.
Wolves XI: Patricio, Coady, Bennett, Boly, Jonny, Neves, Moutinho, Doherty, Costa, Cavaleiro, Jimenez.
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5 years, 7 months ago2 saves from Patricio would be ideal