Harry Maguire (£4.9m) will be out for a “few weeks” after picking up a muscle injury in Sunday’s draw with Aston Villa.
The England international hobbled off just before half-time at Villa Park, failing to return after the interval.
Maguire himself confirmed the extent of the injury on Tuesday.
“Frustrated to pick up an injury at the weekend, will be a few weeks on the sideline for me but I’ll come back stronger.” – Harry Maguire
Meanwhile, teammates Alejandro Garnacho (£6.3m) and Noussair Mazraoui (£4.6m) have pulled out of their national team squads.
Manchester United say that Garnacho “has been managing an issue over the last week”.
Mazraoui, who came off at half-time in Gameweek 7, did not join up with Morocco “as a precaution”.
It later transpired that the full-back had undergone a minor heart procedure after experiencing palpitations. He is expected to return within “a few weeks”.
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